中药辛鹅鼻喷剂联合氯苯那敏治疗上气道咳嗽综合征及对慢性鼻-鼻窦炎治疗作用探讨

Xin Goose Nasal Spray plus Chlorpheniramine in Treatment of Upper Airway Cough Syndrome and Discussion on Treatment of Chronic Rhinosinusitis

目的:探讨中药辛鹅鼻喷剂联合氯苯那敏治疗上气道咳嗽综合征及对慢性鼻炎-鼻窦炎的治疗作用相关。方法:选择2011年9月—2012年9月在本院耳鼻喉科门诊就诊,诊断为上气道咳嗽综合征伴慢性鼻-鼻窦炎患者,分为对照组20例患者,服用氯苯那敏4 mg/次,2～3次/d;治疗组38例患者,在对照组基础上应用辛鹅鼻喷剂,每个鼻孔各2～3喷/次,2～3次/d。治疗2周后评估疗效。采用门诊或电话随访,分析其疗效及有效组与无效组两组患者间合并鼻炎-鼻窦炎患者伴随症状的改善情况。结果:治疗组共38例患者入选本试验,36例完成随访研究,治疗有效率为86.1%,有效患者的伴随症状都有不同程度的改善,咳嗽与伴随症状的改善完全一致,咳嗽治愈的20例患者中伴随症状完全消失占75%(15/20),在有效及治疗无效组伴随症状均有明显改善;对照组共20例患者入选本试验,18例完成随访研究,治疗有效率为61.1%,治疗有效患者的伴随症状都有不同程度的改善,但咳嗽与伴随症状的改善并不完全一致,咳嗽治愈的5例患者中,伴随症状完全消失的仅占60%(3/5),在有效及无效组伴随症状均未完全消失。结论:中药辛鹅鼻喷剂能有效治疗UACS,且对CRS有明显的治疗作用;氯苯那敏治疗上气道咳嗽综合征与其对鼻炎-鼻窦炎的治疗作用无关。

Objective ： To study the effects of traditional Chinese medicine （TCM） Xin Goose Nasal Spray combined with chlor- pheniramine in the treatment of upper airway cough syndrome and in the treatment of chronic rhinitis - sinusitis. Methods ： From September 2011 to September 2012, patients in our hospital otolaryngology outpatient diagnosed as airway cough syndrome with chronic nasal sinusitis were selected. The control group had 20 patients, taking chlorobenzene 4 rag/time,2 - 3 times/d. Treat- ment group had 38 patients, on the basis of chlorobenzene, adding Xin Goose Nasal Spray in each nostril 2 -3 times,2 -3 times/ d. Outcomes assessment were measured after 2 weeks of treatment. By outpatient service or telephone follow - up, its curative effect was analyzed and symptoms improvement in the effective and ineffective groups. Results：In the treatment group,a total of 38 patients were selected in this experiment. 36 patients underwent follow - up study, and the treatment effective rate was 86.1% , ef- fective in patients with symptoms had different degrees of improvement, cough and accompanying symptoms improvement were completely consistent. 20 cases of cough cured with complete resolution of symptoms accounted for 75% （15/20）. The valid and invalid treatment group symptoms were significantly improved. In control group, a total of 20 patients were selected in this experi- ment, 18 cases completed the follow - up study, and the treatment effective rate was 6l. 1%. The effective treatment in patients with symptoms had different degrees of improvement, but the cough and the accompanying symptoms improvement were not entire- ly consistent. 5 patients with cough cured completed resolution of symptoms,accounting for only 60% （3/5）. In the effective and ineffective groups, accompanied symptoms did not disappear completely. Conclusion：Chinese medicine Xin Goose Nasal Spray is an effective treatment, and has obvious therapy effect to CRS. Chlorobenzeneg effect on treating airway cough syndrome has no re- lation with its function on treating rhinitis and sinusitis.