慢性咳嗽患者FENO水平与中医辨证分析

FENO Level and TCM Syndrome Analysis of Patients with Chronic Cough Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine

目的:调查慢性咳嗽患者FENO水平,并按照中医辨证进行分析。方法:应用瑞典尼尔斯(NIOX)《呼出一氧化氮测定系统》进行检测,呼气流速50 mL/s,呼气时间6～10 s。选择142例慢性咳嗽非吸烟患者,进行呼出一氧化氮测定,并对所有患者进行中医证候分型。结果:142例慢性咳嗽患者FENO均值(40.947±43.148)ppb,最低值5.1 ppb,最高值260 ppb;中有75例患者(52.82%)>25 ppb;按照慢性咳嗽的中医证候诊断,风痰袭窍证38例患者FENO平均值最高,为(54.76±56.391)ppb,而胃气上逆证30例患者FENO平均值最低,为(23.940±17.742)ppb;且经过组间比较,属胃气上逆证患者FENO水平与其它3个证型间均具有统计学差异;肝火犯肺证与风痰袭窍证比较也具有统计学差异,其它组间比较无统计学差异。结论:慢性咳嗽患者FENO平均值明显升高,慢性咳嗽患者进行FENO检查有助于疾病的病因病机分析、辨证论治,为临床治疗提供依据。

Objective ：To survey the FENO level of patients with chronic cough,and analyze according to TCM. Methods：Swe- den Nils （NIOX） exhaled nitric oxide measurement system was used to detect,with expiratory flow rate 50 mL/s and expiratorytime 6 to 10 s. 142 patients with chronic cough non - smoking patients were tested by measurement exhaled nitric oxide, recording the syndrome differentiation of TCM. Results ： FENO mean value of 142 patients with chronic cough was （40. 947 ± 43. 148 ） ppb, lowest value 5.1 ppb,the highest value 260 ppb ;75 patients （52.82%） 〉 25 ppb;accordance with the chronic cough syndrome of TCM diagnosis,wind phlegm syndrome in 38 patients,the FENO highest average was （54.76 ± 56. 391 ） ppb,syndrome of ad- verse rising of stomach qi patients＇average value was the lowest patients （23. 940 ± 17. 742） ppb. And after comparison between groups, syndrome of adverse rising of stomach qi patients＇FENO level had significant difference compared with other three groups. Syndrome of liver fire invading lung and wind phlegm syndrome also had statistical difference, and there was no statistically signif- icant difference between the other groups. Conclusion：The chronic cough patients＂ FENO value was significantly increased. The FENO analysis can be contribute to disease etiology and pathogenesis, diagnosis and treatment, providing the basis for clinical treatment.