不同剂量促性腺激素释放激素激动剂长方案中黄体生成素水平变化及临床意义

Serum LH levels in different forms and doses of GnRH agonist long protocol and its clinical significance

不同剂型和剂量的促性腺激素释放激素激动剂(GnRH-a)对垂体的抑制程度不同,因而不同剂型和剂量的GnRH-a长方案中血清黄体生成素(LH)水平也有所不同,从而导致各种方案的临床特征不同。目前研究表明,与短效GnRH-a长方案相比,长效GnRH-a长方案中,促性腺激素(Gn)的使用时间和剂量明显增多,但是二者的临床结局,包括临床妊娠率、活产率、卵巢过度刺激综合征发生率等均无显著性差异。

Different degree of pituitary suppression and various serum LH levels were achieved by using different forms or doses of GnRH agonist （GnRH-a） in long protocol. Therefore the clinical characteristics were also diverse among different long protocols. Compared with short acting GnRH-a, the duration and dosage of exogenous gonadotropin significantly increased in depot GnRH-a long protocol, while the clinical outcomes, such as clinical pregnancy rate, live birth rate and ovarian hyperstimulation syndrome rate, were comparable between the two groups.