期刊文献+

基于认知储备与内源性神经保护的痴呆防治新策略 被引量:3

A new preventive strategy for dementia based on cogniti1 reserve and endogenous neuroprotection
原文传递
导出
摘要 目前认为,多数老年期痴呆的发生和发展是基因与环境的相互作用,并且存在多靶点多通路的交互影响。病理研究显示,多数老年期痴呆患者大脑中同时存在多种病理改变[包括阿尔茨海默病(Alzheimer’Sdisease,AD)样病理、血管性病理改变及路易小体形成等],
作者 章军建 杨英
出处 《中华老年医学杂志》 CAS CSCD 北大核心 2013年第10期1029-1032,共4页 Chinese Journal of Geriatrics
关键词 痴呆 认知障碍 Dementia Cognition disorders
  • 相关文献

参考文献32

  • 1Fotuhi M, Hachinski V, Whitehouse PJ. Changing perspectives regarding late-life dementia. Nat Rev Neurol, 2009, 5649-658.
  • 2Topiwala A, Ebmeier KP. Vascular changes and brain plasticity: a new approach to neurodegenerative diseases. Am J Neurodegener Dis, 2012, 1 .. 152-159.
  • 3Stranahan AM, Mattson MP. Recruiting adaptive cellular stress responses for successful brain ageing. Nature, 2012, 13..209-216.
  • 4Iadecola C. The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. Aeta Neuropathol, 2010,120:287 -296.
  • 5Simpson JE, Ince PG, Haynes LJ, et al. MRC Cognitive Function and Ageing Neuropathology Study Group. Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain. Neuropathol Appl Neurobiol, 2010, 36:25-40.
  • 6Zhang J J, Liu H. New insights into the treatment of vascular cognitive impairment based on the mechanisms of chronic cerebral hypoperfusion. Natl MedJ Chin, 2011, 91:1009-1011.
  • 7Scarmeas N, Albert SM, Manly J J, et al. Education and rates of cognitive decline in incident Alzheimer's disease. J Neurol Neurosurg Psychiatry, 2006, 77: 308-316.
  • 8Scarmeas N, Levy G, Tang MX, et al. Influence of leisure activity on the incidence of Alzheimer's disease. Neurology, 2001, 57:2236-2242.
  • 9Stern Y, Alexander GE, Prohovnik I, et al. Inverserelationship between education and parietotemporal perfusion deficit in Alzheimer's disease. Ann Neurol, 1992, 32:371- 375.
  • 10Stern Y. Cognitive reserve in ageing and Alzheimer's disease. Lancet Neurol, 2012, 111006 1012.

同被引文献20

引证文献3

二级引证文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部