可注射性异体植骨治疗股骨粗隆间骨折的骨缺损(英文)

Injectable allograft bone matrix to repair bone defect in femur intertrochanteric fractures

[目的]自体骨与异体骨混合材料治疗骨缺损的疗效评估。[方法]前瞻性研究病例来源于2002年2月～2010年4月103例股骨粗隆间骨折伴有严重骨缺损的患者,并都经过经皮植入自体骨和可注射性异性脱钙骨基质混合剂治疗。[结果]103例患者中,67例(66.05%)获得了定期随访,平均随访时间为4.95年(2～8年)。其中60例(89.55%)通过经皮植骨治疗平均骨愈合时间为7.3个月(3个月～2年),7例死于其他疾病。[结论]这种方法治疗骨缺损与标准的取自体髂骨植骨相比同样有效,并具有降低并发症、减少治疗成本和缩短住院天数等独特优势。

[Objective]To evaluate the outcome of bone defect by using Injectable autologous bone marrow and allograft bone matrix.[Method]From February 2002 to April 2010,103 patients with serious bone defect of femur intertrochanteric fractures were entered into a prospective study.The only therapeutic intervention was the percutaneous administration of a mixture of autologous bone marrow and allograft demineralized bone matrix.[Result]From these 103 cases,67 cases( 65.05%) were got regular follow-up.The average follow-up period was 4.95 years( range from 2 to 8 years).Among this group,60 of the percutaneous treatments( 89.55%) resulted in union at an average of 7.3 months( range from 3 months to 2 years).7 cases died of other diseases.[Conclusion]This method of treating bone defect is as successful as standard iliac crest autologous bone grafting and offers the distinct advantages of decreased morbidity,reduced costs,and shorter hospitalization.