摘要
Neuritin是神经营养因子家族中的一个新成员,其基因cpg15(candidate plasticity-related gene 15)可由神经活动或神经营养素(neurotrophins,NTs)激活。实验表明neuritin能够促进神经元突起的生长和分支,在神经元可塑性及神经元再生中发挥着重要的作用。近年来的研究证实,neuritin不仅参与神经系统中多项生理功能的调节,还在血管生成以及相关肿瘤的发生中扮演着重要角色。本文将综述neuritin蛋白的翻译表达和调控机理、生物学效用,并围绕neuritin如何发挥其生物活性及目前研究中存在的热点和难点进行讨论。
Neuritin is a new member of the neurotrophic factor family, whose gene is named cpgl5 （candidate plasticity-related gene 15） and can be activated by neural activity or neurotrophins （NTs）. Experiments show that neuritin is able to promote the growth and branching of neurites, and plays an important role in neuronal plasticity and neuronal regeneration. Recent studies have proved that neuritin is not only involved in the regulation of various physiological functions in the nervous system, but also related in angiogene- sis and tumorigenesis. Here we review the mechanisms involved in cpg15 expression and regulation, biological effects of neuritin, and how neuritin plays its biological activities. The hot issues and difficulties in the study of neuritin are also discussed.
出处
《生理学报》
CAS
CSCD
北大核心
2013年第5期483-488,共6页
Acta Physiologica Sinica
基金
supported by the National Natural Science Foundation of China(No.31070745)
Fund for Key Disciplines of Shanghai Municipal Education Commission
China(No.B 111)
