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胃癌组织中RAD51及CHK1的表达及意义 被引量：2

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摘要 目的探讨RAD51及细胞周期检测点激酶1(cell cycle checkpointkinase 1,CHK1)在胃癌中的表达及意义。方法采用免疫组化EnVision两步法检测67例胃癌组织和21例正常胃黏膜组织中RAD51及CHK1蛋白表达,并分析其与胃癌临床病理征特的关系。结果胃癌组织中RAD51及CHK1蛋白表达明显高于正常胃黏膜组织(P<0.05)。RAD51蛋白表达与胃癌的病理分化程度、侵犯深度、有无淋巴结转移有关(P<0.05)。CHK1蛋白表达与胃癌病理分化程度有关(P<0.05)。胃癌组织中RAD51和CHK1蛋白表达呈正相关(P<0.05)。结论 RAD51及CHK1蛋白在胃癌组织中呈高表达,二者在胃癌发生、发展及生物学行为中可能起到重要作用。
作者 闫静波 卫茹
机构地区 河北省邢台市人民医院病理科 河北省邢台市医学高等专科学校
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2013年第10期1128-1130,共3页 Chinese Journal of Clinical and Experimental Pathology
关键词 胃肿瘤 DNA修复蛋白 RAD51 CHK1
分类号 R735.2 [医药卫生—肿瘤]
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参考文献15

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二级参考文献12

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共引文献9

同被引文献25

  • 1王玉祥,祝淑钗,王鑫,封巍,李娟,沈文斌.CHK1和CHK2在食管癌组织中的表达[J].肿瘤防治研究,2006,33(3):171-174. 被引量：10
  • 2王玉祥,祝淑钗,封巍,李娟,苏景伟,李任.CHK1和CHK2 shRNA转染对食管癌细胞照射后G_2期阻滞的影响[J].中华肿瘤杂志,2006,28(8):572-577. 被引量：15
  • 3黄晓园,高庆蕾,庄亮,曹阳,马全富,周剑峰,马丁.Chk1/2和Plk1蛋白在宫颈良恶性病变组织中的表达及其意义[J].中国癌症杂志,2007,17(6):429-432. 被引量：12
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  • 5陈忠民.PTEN通过抑制P13-AKT信号通路上调Rad51基因的表达[J].中国生物化学与分子生物学报,2009,2(24):192-194.
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  • 7Connell PP. Pilot study examining tumor expression of RAD51 and clinical outcomes in human head cancers [J]. Int J Oncol, 2006,28 : 1113-1119.
  • 8Hannay JA. Rad51 overexpression conyributes to chem. Oresistance in hum an soft tissue sarcoma ceslls a role for p53/activator protein 2 transcriptional regulation [J]. Mol Cancer Ther,2007,6(5) :1650-1660.
  • 9Bahassi EM. The checkpoint kinase ehkl and ehk2 regu- late the functional associations between hBRCA2 and Rad51 in response to DNA damage [J]. Oncogene,2008, 27 (2) : 3977-3985.
  • 10Romanowicz-Makowska H,Smolarz B,Samulak D. A single nu-cleotide polymorphism in the 5'untranslated region of RAD51 and ovari-an cancer risk in Polish women[J].European Journal of gynaecological oncology,2012,(04):406-410.

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临床与实验病理学杂志
2013年 第10期

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