基于web肿瘤数据库应用的系统评价

A Systematic Evaluation of Application of the web-based Cancer Database

用系统评价的方法对国内外web肿瘤数据库应用的发展现状进行评估,为我国web肿瘤数据库发展给予理论和实践的指导。计算机检索Ovid-MEDLINE、Springerlink、EBSCOhost以及Wiley Online Library和中国知网(CNKI)从1995年1月-2011年12月的相关文献,并对这些文章的参考文献进行手工检索,按照事先制定的纳入与排除标准选择文献,并对相关资料进行提取分析。最终,有1 244篇文章来自对以上数据库的计算机检索,另有19篇文章来自以上文章的参考文献。在上述文献中,有31篇文章符合纳入排除标准并对其进行了证据提取和评价。对其证据的分析表明,美国在web肿瘤数据库数量上以占总数的26%排在第一位,39%的数据库为肿瘤综合数据库,单病种数据库以前列腺癌,乳腺癌最多,均占10%,32%的肿瘤数据库包含了基因研究的数据信息。在已知的技术应用方面,以MySQL和PHP技术运用最广泛,均占到了23%左右。

In order to support the theory and practice of the web-based cancer database development in China, we ap- plied a systematic evaluation to assess the development condition of the web based cancer databases at home and a- broad. We performed computer-based retrieval of the Ovid-MEDLINE, Springerlink, EBSCOhost, Wiley Online Li- brary and CNKI databases, the papers of which were published between Jan. 1995 and Dec. 2011,and retrieved the references of these papers by hand. We selected qualified papers according to the pre-established inclusion and exclu- sion criteria, and carried out information extraction and analysis of the papers. Eventually, searching the online data- base, we obtained 1 244 papers, and checking the reference lists, we found other 19 articles. Thirty-one articles met the inclusion and exclusion criteria and we extracted the proofs and assessed them. Analyzing these evidences showed that the USA counted for 26% in the first place. Thirty-nine percent of these web-based cancer databases are com- prehensive cancer databases. As for single cancer databases, breast cancer and prostatic cancer are on the top, both counting for 10% respectively. Thirty-two percent of the cancer database are associated with cancer gene informa- tion. For the technical applications, MySQL and PHP applied most widely,nearly 23 % each.