羊水干细胞在再生医学的研究进展

RESEARCH DEVELOPMENT OF AMNIOTIC FLUID-DERIVED STEM CELLS IN REGENERATIVE MEDICINE

目的对羊水干细胞(amniotic fluid-derived stem cells,AFSCs)的研究进展及在再生医学等领域的发展进行综述,探讨今后AFSCs研究的相关问题。方法查阅近年来AFSCs的相关文献,对AFSCs在再生医学领域研究的成果及其基础与临床研究展望进行综述。结果目前研究已表明AFSCs具有多向分化潜能,在组织工程或细胞替代治疗的研究中展现出广阔的应用前景。结论羊水取材简便,对母婴创伤小,无致瘤性,无伦理学方面的限制,使AFSCs极有希望成为再生医学、抗肿瘤等领域中理想的种子细胞,具有广泛研究价值。

ObjectiveTo review the latest development of amniotic fluid-derived stem cells （AFSCs） in regenerative medicine, and to discuss issues related to the studies in the field of AFSCs. MethodsThe recent articles about AFSCs were extensively reviewed. The important knowledge of AFSCs was introduced in the field of regenerative medicine, and the basic and clinical researches of AFSCs were summarized and discussed. ResultsCurrently, it is confirmed that AFSCs have a multi-directional differentiation capacity, therefore, they have a wide application prospect in regenerative medicine, anti-tumor, and other fields. ConclusionAFSCs will become one of the ideal seed cells in the field of regenerative medicine with extensive research value because of the advantages of easy amniotic fluid sampling, little maternal and child trauma, no tumorigenesis, and no ethical restrictions.