食蟹猴麻疹胎传抗体及其仔猴初次接种麻疹疫苗免疫效果的研究

The Antibody against Measles through Maternal-transferred and Immuno-response to First Measles Vaccine in Macaca fascicularis Infants

目的 研究食蟹猴麻疹胎传抗体情况,探讨食蟹猴麻疹疫苗接种起始月龄 方法 选取麻疹抗体阴性、离乳后的63头繁殖食蟹母猴,其中58头母猴随机平均分成2组,并接种麻疹疫苗,另5头接种疫苗作为第3组,3组母猴均与正常公猴交配.对3组的出生仔猴体内麻疹抗体进行持续的检测,对第1组和第3组仔猴在6月龄进行免疫接种,第2组仔猴在8月龄首次免疫.结果 接种疫苗母猴所生1月龄仔猴与其母亲的抗体水平一致,并随着仔猴月龄增加,其体内抗体逐步降低,5月龄时抗体阳性率降到7％以下,6月龄仔猴免疫后20 d,第1组17头（17/19,89.47％）和第3组3头（3/3,100％）仔猴产生抗体;第2组8月龄首免,免疫后20 d,所有猴能产生抗体.6月龄时,仔猴体内已经没有麻疹抗体,8月龄仔猴初免效果优于6月龄,但是差异不显著.结论 为降低仔猴在麻疹疫苗初次免疫月龄前发病,减少易感动物,实验猴麻疹疫苗初免时间为6月龄.

Objective To study the maternal-transferred measles antibody in order to know the optimal first measles vaccine-inoculated on Macaca fascicularis infants.Methods The 63 mother Macacafascicularis,with measles antibody negative,were selected after weaning,and 58 of them were vaccinated with measles and randomly averaged into two groups.Another five female didn＇t vaccinate as the third group.The females of all the groups were mated with fertile male monkeys,the measles antibody were continuously tested in mothers and their infants.Results There was great correlation between maternal measles antibody level and newborn,and growth with age,maternal transferred measles antibody levels in newborns reduced gradually,up to 5 month,antibody titer less than 7%.After 20 days vaccination in 6 month old infants of the first group and the third group,and 8 month old infants of the second group,18 （18/19,94.74%） monkeys of the first group and 3 （3/3,100%） monkeys of the third group produced antibody,The second group all could produce antibody.To 6 month,measles antibody of all infants is disappeared.The efficacy of immune in 8 month old infants is better than 6 month old infants,But the difference is not significant（P〈0.05）.Conclusion In order to decrease susceptible infants and prevent measles cases in infants before vaccination age（month）.It was recommendated that the first measles vaccine in Macaca Fascicularis infants is 6 monthold.