肿瘤坏死因子-α在慢性血吸虫病患者结肠组织中的表达及意义

Expression and Significance of Tumor Necrosis Factor alpha in Colon Tissue of Patients with Chronic Schistosomiasis

目的检测肿瘤坏死因子-α(TNF-α)在慢性血吸虫病患者结肠组织中的表达变化,探讨血吸虫病对靶器官的损害,为评价血吸虫病的危害及血吸虫病的防治提供一定的实验室依据.方法运用免疫组织化学染色法检测50例慢性血吸虫病患者病变结肠组织及9例正常结肠组织标本中肿瘤坏死因子-ɑ的表达情况.结果与正常对照者相比,慢性血吸虫病患者结肠腺中TNF-α阳性颗粒平均光密度值明显升高(P=0.017),结肠间质中TNF-α阳性颗粒平均光密度值略有升高(P=0.059),但其表达与性别无关.结论慢性血吸虫感染可诱导患者结肠组织中TNF-α的浓度增高,这可能在血吸虫病引起的结肠病理生理变化中起到重要作用.

Objective Detect the tumor necrosis factor- a （TNF- a ） expression changes in colon tissue of patients with chronic schistosomiasis, explore schistosomiasis target organ damage, and provide a laboratory basis for the evaluation of hazards and schistosomiasis prevention and control. Methods The tumor necrosis factor- a expression of colon tissue of 50 patients with chronic schistosomiasis and 9 cases of normal colon tissue were detected using immunohistochemistry staining. Results Compared with normal control, the colon gland in TNF- of - positive particles mean optical density value of chronic schistosomiasis patients was significantly higher （P = 0.017） , colon interstitium of TNF - a - positive particles mean optical density value was slightly higher （P = 0.059） , but its expression has nothing to do with sex. Conclusion Chronic schistosomiasis infection can induce increased concentration of TNF- a in patients with colon tissue of the colon, which may play an important role in causing schistosomiasis pathophysiological changes.