氧化应激与血压和高血压发病关系的研究

Oxidative Stress in Relation to Blood Pressure and Hypertension

目的研究血清超氧化物歧化酶(SOD)、丙二醛(MDA)、尿酸(UA)与血压和高血压患病的关系.方法从2010年5月至7月来健康体检的随机选择506名,检测其SOD、MDA和UA,使用SAS 9.13统计软件进行数据库管理和统计分析.结果与血压正常者相比,高血压患者的SOD活性显著降低(P<0.01),而MDA、UA水平则明显升高(P<0.05).Pearson相关性分析发现SOD活性与血压、UA呈负相关(P<0.01),而MDA与血压、UA呈正相关(P<0.05).按照SOD、MDA的三分位数进行分组,在调整协变量后,SOD低组、中组和高组之间收缩压(Ptrend=0.02)和舒张压(Ptrend=0.04)差别均有统计学意义(P<0.05),高组的血压低于低组;MDA低组、中组和高组之间收缩压(Ptrend=0.01)和舒张压(Ptrend=0.003)差别均有统计学意义(P<0.05),高组的血压显著高于低组.结论高血压患者存在氧化和抗氧化能力失衡,氧化应激可能在高血压的发病过程中起一定的作用.

Objectives To investigate the associations of serum superoxide dismutase （ SOD） , malondialdehyde （MDA）, and uric acid （UA） with blood pressure and the prevalence of hypertension in a Chinese population. Methods We measured serum superoxide dismutase （SOD）, malondialdehyde （MDA） and uric acid （UA） in 506 randomly selected participants. For database management and statistical analysis, we used the SAS 9.13 Software. Results Compared with normotensive participants, hypertensive patients had significantly lower serum levels of superoxide dismutase activity （ =0.0002）, and higher serum levels of malondialdehyde and uric acid （ 〈0.05） .Univariate analysis indicated that serum superoxide dismutase activity was negatively associated with blood pressure, and serum levels of uric acid （P 0.0001）;while serum levels of malondialdehyde was positively associated with blood pressure, and serum levels of uric acid （P 0.05） . There was significant difference in systolic （Ptrend=0.02） and diastolic blood pressure （Ptrend=0.04） between three groups defined by tertiles of serum levels of superoxide dismutase, with a lower blood pressure in the highest tertile than in the lowest tertile. Furthermore, the systolic （Ptrend=0.01） and diastolic blood pressure （Ptrend=0.003） in the highest tertile, which defied by the serum levels of malondialdehyde, were significantly higher than those in the lowest tertile. Conclusions Hypertensive patients have a disturbed oxidative and anti-oxidative balance. Oxidative stress may play a role in the pathogenesis of hypertension in Chinese.