IL-1A3'非翻译区rs3783553多态性与颅内动脉瘤的关系

Association between rs3783553 polymorphism in 3' untranslational region of IL-1A and risk of intracranial aneurysm

目的探讨微小RNA-122(miRNA-122)靶基因白细胞介素1A(IL-1A)3'非翻译区(3'UTR)rs3783553插入(ins)/缺失(del)多态性与颅内动脉瘤的关联。方法采用聚合酶链反应方法检测IL-1A 3'3'UTR区rs3783553多态性在173例对照组和142例颅内动脉瘤组的分布差异。结果颅内动脉瘤组del和ins等位基因频率分别为70.4%和29.6%;对照组两等位基因频率分别为61.8%和38.2%。与del等位基因相比,ins等位基因显著降低了颅内动脉瘤的发病风险,差异具有统计学意义(χ2=5.09,P=0.024)。根据性别、年龄和动脉瘤数量等临床特征进行亚组分析,未发现IL-1A 3'UTR区rs3783553多态性与此临床特征存在明显相关性。结论 IL-1A 3'3'UTR区rs3783553插入/缺失多态性可能与中国人群颅内动脉瘤的发病相关。

Objective To investigate the association between insertion （ins）/deletion （de l） polymorphism （i. e. rs3783553） at microRNA-122 （miR-122） binding site in the interleukin-lA （IL-1A） 3＂untranslated region （3＂ UTR） and risk of intracranial aneurysm （IA）. Methods The rs3783553 polymorphism in the 3 UI＇R of IL-1A was genotyped in 173 healthy controls and 142 patients with IA using polymerase chain reaction method. Results The frequencies of de! and ins alleles of rs3783553 were 70. 4% and 29.6% in patients with IA and 61.8% and 38.2% in controls, respectively. The ins allele was associated with a significantly decreased risk of IA compared with the del allele （X2 =5.09, P =0. 024）. After stratification analyses according to gender, age, and number of IA, no significant association was observed between the rs3783553 polyrnorphism and these clinical features （P 〉 0. 05）. Conclusion The rs3783553 polymorphism in the 3UIIt of IL-1A may be related to the development of IA in a Chinese population.