肺炎支原体肺炎患儿血清白介素-23/白介素-17的表达

The serum levels of IL-17 and IL-23 in children with Mycoplasma pneumoniae pneumonia

目的探讨肺炎支原体(MP)肺炎患儿血清白介素17(IL-17)和白介素23(IL-23)表达的变化及作用。方法选取2012年2月至2012年5月住院肺炎患儿103例,根据MP抗体检测结果分为肺炎支原体肺炎(MPP)组和非MPP组,另选取同期正常体检儿童42例为对照组。所有入选对象均行血清IL-17和IL-23水平及MP抗体测定,对肺炎患儿行免疫球蛋白、C反应蛋白、白细胞总数和中性粒细胞计数检测。结果三组的血清IL-17和IL-23水平差异均有统计学意义(P<0.05),其中MPP组高于非MPP组,两肺炎组均高于对照组,差异均有统计学意义(P均<0.05)。MPP及非MPP组中,免疫球蛋白正常及异常者IL-17和IL-23水平的差异均无统计学意义(P均>0.05),且IL-17和IL-23与中性粒细胞计数均呈正相关(P均<0.05)。结论 IL-17、IL-23在肺部MP感染时参与免疫应答,可能参与MP清除。

Objective To investigate the expression levels and the roles of IL-17 and IL-23 in children with Myeoplasma pneumoniae （MP） pneumonia. Methods One hundred and three children with pneumonia admitted to pediatric department from February to May in 2012 were divided into MP pneumonia group and non-MP pneumonia group according to the results of MP antibody tests. Meanwhile, 42 healthy children were chosen as normal controls. Serum levels of IL-17, IL-23 and MP antibodies were measured in all children. Immunoglobulin, C reactive protein, total white blood cell count and granulocyte count were detected in children with pneumonia. Results The serum levels of IL-17 and IL-23 were significantly different among three groups （P〈0.05）. The children in MP pneumonia group had higher levels of IL-17 and IL-23 than those in non-MP pneumonia group （P〈0.05）. Compared with the control group, levels of IL-17 and IL-23 were higher in two pneumonia groups （P〈0.05）. There was no significant difference in levels of IL-17 and IL-23 between pneumonia patients with normal and with abnormal levels of immunoglobulin （P〉0.05）, while IL-17 and IL-23 levels were both positively correlated with granulocyte count （P〈0.05）.Conclusion IL-17 and IL-23 may be involved in the immune response of MP pneumonia and may contribute to the clearance of pathogens.