平消胶囊同步放疗在食管癌术后的应用价值

Value of combination of Pingxiao capsule and radiotherapy on the treatment of radical esophagectomy of esophageal carcinoma

目的:探讨平消胶囊同步放疗在食管癌术后放疗的应用价值。方法:84例食管癌术后三维适形放疗(3D-CRT)患者分为两组,39例(试验组)放疗同步口服平消胶囊,每天3次,每次5粒;45例(对照组)仅单纯术后放疗。结果:随访率95.2%。实验组1、3年总生存率(OS)为90.4%、70.5%,中位生存期35个月;对照组1、3年OS为82.2%、47.9%,中位生存期23个月,差异有显著性(P=0.020)。实验组1、3年无病生存率(DFS)为87.2%、66.1%,中位无病生存期33个月;对照组DFS为66.7%、44.4%,中位无病生存期20个月,差异有统计学意义(P=0.028)。结论:平消胶囊同步放疗可以提高食管癌术后疗效,有放疗增敏作用。

Objective：To investigate the value of combination of Pingxiao capsule and radiotherapy on the radical esophagectomy of esophageal carcinoma. Methods： All 84 patients with esophageal carcinoma undergone radical esophagectomy were divided into two groups,39 patients in experiment group treated by combination of Pingxiao cap- sule and radiotherapy,45 patients in control group treated by radiotherapy alone. Results：The following- up rate was 95.2%. The 1 - ,3 -year OS were 90.4% ,70.5% for experiment group, the median overall survival time was 35 months ;The 1 - ,3 -year OS were 82.2% ,47.9% for control group,the median overall survival time was 23 months （P = 0.020）. The 1 - ,3 -year DFS were 87.2% ,66.1% for experiment group, the median disease -free time was 33 months;The 1 - ,3 -year DFS were 66.7% ,44.4% for control group, the median disease -free time was 20 months （ P = 0. 028 ）. Conclusion： Combination of Pingxiao capsule and radiotherapy can elevate effect and has sensi- tization of radiotherapy.