血清PGⅠ、PGⅡ与CEA、CA72-4联合检测对胃癌的诊断价值

Clinical significance of serum levels of PGⅠ,PGⅡ,CEA and CA72-4 in diagnosis of gastric cancer

目的:探讨血清胃蛋白酶原PGⅠ、PGⅡ及癌胚抗原CEA、糖类抗原CA72-4联合检测对胃癌的诊断价值。方法:采用全自动生化分析仪及电化学发光仪检测40例胃癌患者和50例健康人血清中胃蛋白酶原PGⅠ、PGⅡ、PGⅠ/PGⅡ比值、CEA及CA72-4的水平并进行比较。结果:胃癌患者血清胃蛋白酶原PGⅠ水平和PGⅠ/PGⅡ比值明显低于正常对照组(P<0.01)。而CEA和CA72-4水平明显高于正常对照组(P<0.01)。血清胃蛋白酶原PGⅠ、PGⅠ/PGⅡ比值的敏感性和特异性要优于CEA、CA72-4。联合检测与单项检测相比,敏感度、特异性显著提高,与临床诊断相符性显著提高(kappa值分别为0.663,0.660)。结论:胃癌患者血清PGⅠ、PGⅠ/PGⅡ比值、CEA和CA72-4的检测对胃癌的诊断有一定的临床意义。四项标志物联合检测可有效提高胃癌诊断的敏感度和特异性,可以作为胃癌的筛查手段。

Objective：To explore the clinical significance of combined detection of serum levels of PGⅠ, PG Ⅱ , CEA and CA72 - 4 in diagnosis of gastric cancer. Methods： Forty patients with gastric cancer in study group and 50 healthy persons in control group were enrolled in this study, and the sera were separated for determination of PG Ⅰ, PG Ⅱ, CEA and CA72 -4 by automatic biochemical analyzer and electrochemiluminescence immnnoassay. Results： The serum PGⅠ and PG Ⅰ/ PG Ⅱ were significantly lower than those in normal control group（P 〈 0.01 ）, while the CEA and CA72 - 4 levels were significantly higher than those in normal control group（ P 〈 0.01 ）. The sensitivity and specificity of PG Ⅰ , PG Ⅰ/ PG Ⅱ were higher than those of CEA, CA72 - 4. The difference between combined detec- tion and single examination in specificity was significant, and the conformity of the clinical diagnosis can significantly be raised. Conclusion：Combined detection of serum levels of PG Ⅰ PG Ⅱ ,CEA and CA72 -4 can significantly raise the sensitivity and accuracy in diagnosis of gastric cancer and has good clinical significance in diagnosis of gastric cancer.