摘要
目的:评价腹腔热灌注化疗对妇科癌性腹水治疗的临床价值。方法:对49例晚期妇科恶性肿瘤合并癌性腹水患者,使用深静脉软管经皮腹腔内置管,经体外循环热灌注治疗后,注入顺铂,观察恶性腹水量的变化。同时检测腹水中的相关肿瘤标志物的变化情况。观察患者一般生活体力状况变化及生活质量情况。结果:行腹腔热灌注化疗后,11例患者腹水减少程度>90%,28例患者腹水减少程度>50%,总有效率79.59%。18.36%的患者发生恶心及呕吐等症状。治疗后患者一般生活状况评分、腹水最大直径等指标较治疗前好转(P<0.01),肿瘤标志物水平均明显低于治疗前(P<0.05)。结论:腹腔热灌注化疗治疗妇科癌性腹水近期疗效好且安全,副作用小,患者耐受性好,是恶性腹水患者较可靠的治疗措施。
Objective:To explore the effects and side effects of intraperitoneal hyperthermal chemotherapy in the treatment of malignant seroperitoneum in gynecology carcinoma. Methods: Total of 49 cases diagnosed as gynecology carcinoma with malignant seroperitoneum, received intraperitoneal hyperthermal chemotherapy combining with DDP. To observe the change in volume of seroperitoneum, and test tumor markers ( CEA, CA125, CA242, CA199, CA153 ). Results:After the treatment, the degree of reduction in the amount of seroperitoneum was greater than 90% in 11 ca- ses ,greater than 50% in 28 cases. The total effective rate was 79.59%. 18.36% of the patients had side effects such as nausea and vomiting. The PS score and maximum diameter of seroperitoneum of the patients after treatment were improved significantly( P 〈 0.01 ). Tumor markers were significantly lower than before treatment( P 〈 0.05 ). Con- clusion:Intraperitoneal hyperthermal chemotherapy in the treatment of gynecological malignant seroperitoneum is ef- fective, safe and tolerable with slight side effects.
出处
《现代肿瘤医学》
CAS
2013年第10期2303-2305,共3页
Journal of Modern Oncology
基金
陕西省卫生厅科研基金项目资助(编号:2012D85)
关键词
热灌注治疗
癌性腹水
肿瘤标志物
顺铂
intraperitoneal hyperthermal chemotherapy
malignant seroperitoneum
tumor markers
Cisplatin