摘要
本实验探讨5种云南锡矿粉及4种金属化合物的潜在诱变性以及与职业性肺癌高发率之间的关系。大鼠经气管灌注这些矿粉和金属化合物后,于不同时间进行细胞学制片,观察其对大鼠骨髓细胞和肺巨噬细胞的微核率和核碎解率的影响。发现5种云锡矿粉和2种金属化合物(SnO_2和Fe_2O_3)均能诱发大鼠骨髓细胞微核和核碎解的增加,处理后1天和10天时核碎解率高于微核率,并与对照相比差异显著,20天和30天时微核率高于核碎解率,与对照相比也有显著差异。 5种矿粉和4种金属化合物均能诱发大鼠肺巨噬细胞微核率和核碎解率的变化,处理后10天和20天时核碎解率高于微核率与对照相比差异显著。
This paper emphasizes on the correlation between the highoccurring occupational lung cancer and potential mutagenicity of five kinds of Yunnan tin ore powder and four kinds of metallic compound. After treatment of rats by administration through trachea with these ore powder and compounds, the cylological preparations are made at various intervals for observing the effects of these ore powder and metallic compound on the frequencies of micronu-clcus and karyorrhexis of rat bone marrow cells and lung macrophages. The results are as following:
1. All the ore powder and two kinds of metallic compound SnO2 and Fe2O3 can induce micronuclci and karyorrhexis in bone marrow cells. On first and 10th day, the frequency of karyorrhexis is higher than that of micronuclci and differs significantly from that of the control and vice versa on 20th and 30th day.
2. All of the ore powder and metallic compound can also induce mieronu-clci and karyorrhexis in lung maerophages, and on 10th and 20th day, the frequency of karyorrhexis is as the same as that in bone marrow cells.
关键词
云锡矿粉
金属化合物
大鼠
微核率
Yunnan tin ore powder, Metallic compound, Rats microuuclci,lung tnacrophages, Bono marrow cells
