柳氮磺吡啶配合中药口服灌肠治疗溃疡性结肠炎40例疗效观察

Sulfasalazine Combined with Chinese Herbs for Oral Administration and Retention Enema in Treating Ulcera- tive Colitis：Clinical Observation of 40 Cases

为观察中西药配合治疗溃疡性结肠炎的l临床疗效，将75例溃疡性结肠炎患者分为观察组40例和对照组35例，对照组患者给予口服柳氮磺吡啶治疗，观察组在此基础上配合中药口服与保留灌肠治疗。4周为1个疗程，3个疗程后比较两组疗效。结果显示，观察组的有效率显著高于对照组（97．5％VS54．3％，P〈0．05）；对两组42例治愈患者追踪随访1年，观察组复发率显著低于对照组（40．7％vs 73．3％，P〈0.05）。结果表明，柳氮磺吡啶配合中药口服、保留灌肠治疗溃疡性结肠炎较单纯柳氮磺吡啶口服治疗临床效果更为显著，且复发率低。

Abstract This study was to observe the clinical efficacy of ulcerative colitis treated by integrated Chinese and western medicine,75 cases were randomly divided into observation group （ n =40）and control group（ n = 35）. Sulfasalazine was given to control group orally, while herbal decoction to observation group orally and by retention enema in addition. One treatment course all lasted 4 weeks, and both groups were com pared for clinical efficacy after three treatment courses. The results showed that observation group had a significantly higher effective rate than control group（97.5% vs 54.3%, P 〈0.05）. For the cured 42 cases in both groups, the recurrence rate was significantly lower in observation group than in control group （40.7% vs 73.3%, P 〈O. 05） after one year of follow-up. It is concluded that sulfasalazine is more effec- tive for ulcerative colitis in combination with Chinese herbs for oral administration and reention enema than sulfasalazine,and also has a low recurrence rate.