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子宫内膜轻创术对子宫内膜容受相关因子表达的影响 被引量:11

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摘要 目的:探讨子宫内膜轻创术对提高子宫内膜容受性的作用及轻创的最佳时间。方法:对90例行体外受精(IVF)患者,随机分为月经第3天行轻创组30例(A组),月经第7天行轻创组30例(B组),月经第11天行轻创组30例(C组),采取内膜微活检的方法,获取轻创前1周期及轻创周期排卵后1周的子宫内膜标本,在扫描电镜下观察胞饮突,免疫组化定位及半定量检测整合素β3,同源框基因(HOXA-10)的表达。结果:90例患者轻创前后比较,分别为胞饮突丰富21.11%vs37.78%,中等16.67%vs 31.11%,较少62.22%vs 31.11%;整合素β34.60±1.25vs 7.62±1.64,同源框基因(HOXA-10)5.60±1.76vs 8.72±1.95,清创术前后均有统计学差异(P<0.05)。A组、B组和C组清创术后比较,分别为胞饮突丰富50%vs 30%vs 33.33%,中等30%vs 36.67%vs 26.67%,较少20%vs 33.33%vs 40%,整合素β37.42±1.75vs 5.12±0.96vs 6.08±1.02,同源框基因(HOXA-10)8.98±1.24vs 6.85±1.02vs 5.99±1.92,A组与B、C组比较均有统计学差异(P<0.05)。结论:胞饮突、整合素β3、HOXA-10是子宫内膜着床期的重要相关因子,它们的高表达与子宫内膜容受性密切相关,而轻创术可以增加三者的表达,从而提高子宫内膜容受性,并且月经第3天轻创对提高子宫内膜容受性可能更有意义。
出处 《陕西医学杂志》 CAS 2013年第10期1282-1284,1287,共4页 Shaanxi Medical Journal
基金 常州市社会发展科技计划项目(CS20102015)
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