结合雌激素软膏对宫颈因素性不孕患者的治疗结局

Clinical observation of conjugated estrogens cream to treat infertility caused by cervical factors

目的了解结合雌激素软膏是否影响不孕患者的宫颈粘液的形状,是否可以增加不孕患者的妊娠率。方法对确诊为不孕症的42例患者(110个周期)进行前瞻性分析。其中一组指导同房,行宫颈粘液评分和性交后试验。另一组,在治疗过程中局部使用结合雌激素软膏,观察宫颈评分及妊娠结局。结果对照组与倍美力软膏阴道局部用药组宫颈粘液总分(对照组6.1636±2.0436分,倍美力软膏阴道用药组8.6364±1.6258分)及子宫内膜厚度(对照组6.4±1.278 mm,倍美力软膏阴道用药组8.4836±0.9527 mm)二者间比较均有统计学差异。二者妊娠结局(对照组11例,倍美力软膏阴道用药组19例)比较则无显著性差异。结论倍美力软膏阴道局部用药能改善周期中宫颈评分及子宫内膜厚度,但对妊娠结局并无显著影响。单纯改善宫颈情况对增加妊娠率的意义不大。

Objective To explore the efficacy and safety of conjugated estrogens cream usage for cervical factor caused infertility. Method Forty two couples （ one hundred ten cycles） were divided into two groups randomly. In control group, ovulation was documented by a transvaginal ultrasound scan prior to guide intercourse. In study group, put conjugated estrogens cream into vaginas of women. The cervical mucus score, thickness of endometrial and weather pregnancy were studied. Results There was significant differences in cervical mucus score and endome- The thickness of endometrial was 6.4±1. 278mm in control group, but that of study group was 8. 4836± 0. 9527 mm ; the difference was statistically significant （P 〈 0.05 ）. There was no significant difference of pregnant rate in two groups （11 ＆19 ,P 〉 0.05 ）. Conclusion Conjugated estrogens cream can improve the cervical mucus score and endometrial thickness but could not increase pregnant rate distinctly.