金因肽配合口腔护理治疗化疗引起口腔溃疡的疗效观察

Effect observation on treating chemotherapy-induced oral ulcer by rhEGF plus oral care

目的：探讨金因肽联合口腔护理对由化疗所引起的口腔溃疡进行治疗的临床疗效。方法：选择我院从2011年3月～2012年5月接诊的由于化疗所引起的口腔溃疡病人70例，并随机的分为观察组与对照组，每组各35例。观察组在采取常规的口腔护理基础上，在溃疡区域的粘膜上加喷金因肽进行治疗，对照组只给予常规的口腔护理，观察并记录两组患者口腔溃疡的治疗有效率。结果：观察组的治疗有效率高达94.3%，而对照组的治疗有效率仅为71.4%，观察组明显高于对照组，两组之间的差异比较具有统计学的意义（P〈0.05）。结论：金因肽联合口腔护理在治疗由化疗所引起的口腔溃疡时有显著的疗效，此方法简便易行，值得在临床上推广使用。

Objective：To investigate the clinical efficacy of in treatment of rhEGF plus oral care. Methods：In our hospital from March 2011~May 2012 admissions due to 70 cases of oral ulcer patients caused by chemotherapy, and randomly divided into observation group and control group, each group of 35 cases. In the observation group took oral care on the basis of the conventional, and spraying in the ulcer region mucosa due to peptide treatment, the control group only received conventional oral care, observation and treatment records of two patients of oral cavity ulcer efficiency. Results：In the observation group the effective rate reaches as high as 94.3%, while in the control group the effective rate was only 71.4%, the observation group was significantly higher than that of the control group, the differences between the two groups was statistically significant （P〈0.05）. Conclusion：The rhEGF plus oral care has significant effect on treating chemotherapy-induced oral ulcer, this method is simple, it is in clinical use.