乙酰胆碱结合蛋白的特点及应用

The Characterization and Application of Acetylcholine Binding Proteins

乙酰胆碱结合蛋白(acetylcholine-binding proteins,AChBPs)的基本特征、结构特点和激活机制与烟碱型乙酰胆碱受体(the nicotinic acetylcholine recepror,nAChRs)相似.通过对AChBPs晶体结构与功能的研究,能准确阐明nAChRs结构与功能的关系.通过对配体和AChBPs的复合物的晶体结构解析,有助于我们理解配体与nAChRs相互作用的机理,为开发治疗疼痛、成瘾、帕金森症、阿尔茨海默氏症和癫痫等疾病的新药提供理论基础.

Acetylcholine-binding proteins （AChBPs） have been identified from different snails, including Lymnaea stagnalis, Aplysia californica and Bulinus truncatus. As structural homologues of the nicotinic acetylcholine receptors （nAChRs）, AChBPs have similar characteristrics and activation mechanism of nAChRs. Therefore, the crystal structure of AChBPs can provide a structural basis for understanding the structure and function of nAChRs, which would be useful to design new drugs for pain, addiction, Parkinson disease, Alzheimer＇s disease, and epilepsy etc.