坎地沙坦酯中间体甲酯C5的水合肼还原制备

Synthesis of Methyl-3-amino-2-( 2'-cyanobiphenyl-4-yl) methyl] amino benzoate

以二氯甲烷和四氢呋喃为溶剂,活性炭和三氯化铁为催化剂,用水合肼作为硝基还原剂,将3-硝基-2-(2'-氰基联苯-4-基)甲基]氨基苯甲酸甲酯还原为3-氨基-2-[(2'-氰基联苯-4-基)甲基]氨基苯甲酸甲酯,最后经甲醇精制,收率可达93.22%。

Synthesis of hydrazine hydrate as reductant to methyl - 3 - amino - 2 - [ （2＇ - cyanobiphenyl - 4 - yl） methyl ] amino benzoate from methyl - 3 - nitro - 2 - [ （ 2＇ - cyanobiphenyl - 4 - yl） methyl ] amino benzoate, using dichloromethane/tetrahydrofuran as mixed solvent and activated carbon/iron trichloride as mixed catalysts, and purified by methanol. The reaction yield was 93.22%.