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骨髓间充质干细胞治疗椎间盘退行性病变的研究进展

Research Progress of Bone Marrow Mesenchymal Stem Cells in Degenerated Intervertebral Disc
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摘要 对椎间盘退变机制、BMSCs生物学特性、支架材料及细胞因子认识的深入,为BMSCs修复退变的椎间盘组织奠定了基础。研究表明,BMSCs治疗椎间盘退行性病变具有可行性,临床应用前景广阔。本文就BMSCs治疗椎间盘退行性病变的研究进展进行综述。 The further understanding of cellular scaffolds, cell factors, intervertebral disc （IVD） cell pathophysiology and BMSCs biology have laid the foundation of cell-based therapies for IVD degeneration. Moreover, a series of animal studies and vitro experiments also confirm the feasibility and effectiveness of cell-based therapies for IVD degeneration. It shows a wide prospect of clinical application in the future. The current research status of BMSCs in IVD tissue engineering was reviewed.
作者 袁超群 张海龙
机构地区 同济大学附属上海第十人民医院骨科脊柱与微创中心
出处 《组织工程与重建外科杂志》 2013年第5期295-297,共3页 Journal of Tissue Engineering and Reconstructive Surgery
基金 上海市科学技术委员会科研计划项目(114119a2500)
关键词 组织工程 骨髓间充质干细胞 椎间盘 退行性改变 Tissue engineering Bone marrow mesenchymal stem cells Intervertebral disc Degeneration
分类号 Q813.3 [生物学—生物工程]
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组织工程与重建外科杂志
2013年 第5期

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