摘要
目的探讨蒙古族、汉族代谢综合征(Ms)患者瘦素水平的差异及其相关影响因素分析。方法根据MS的诊断标准,从健康体检人群中选取蒙古族、汉族MS患者291例,其中汉族MS患者146例(A组),蒙古族MS患者145例(B组)。采用放射免疫方法检测血清瘦素,同时检测身高、体质量、血压、血糖、血脂、血尿酸(sUA)、胰岛素,并计算体质量指数和胰岛素抵抗指数。结果B组的空腹血糖(FPG)[(6.2±1.5)mmol/L]、低密度脂蛋白胆固醇(LDL-C)[(3.1±0.8)mmol/L]、瘦素[(4.3±2.0)μg/L]、胰岛素[(22.4±16.0)mU/L]以及胰岛素抵抗指数[(6.5±0.5)]和A组的FPG[(6.7±1.7)mmol/L]、LDL.c[(2.7±0.7)mmol/L]、瘦素[(3.4±1.5)μg/L]、胰岛素[(18.8±14.0)mU/L]和胰岛素抵抗指数[(4.7±3.6)]相比差异有统计学意义(t:2.04、2.84、3.47、2.18、4.82,P〈0.01或P〈0.05)。B组的年龄[(46.9±9.8)岁]、收缩压(SBP)[(146.8±17.0)mmHg]、舒张压(DBP)[(90.5±11.6)mlIlHg]、体质量指数[(27.4±2.9)kg/m2]、总胆固醇(TC)[(5.5±1.0)mmol/L]、甘油三酯(TG)[(2.3±1.4)mmol/L]、高密度脂蛋白胆固醇(HDL-C)[(1.3±0.3)mmol/L]和sUA[(320.7±93.6)μmol/L]和A组的年龄[(46.3±8.4)岁]、SBP[(149.1±19.2)mmHg]、DBP[(92.5±13.1)mmHg]、体质量指数[(27.9±3.2)kg/m2]、Tc[(5.5±0.9)mmol/L]、TG[(2.3±1.4)mmol/L]、HDL-C[(1.2±0.4)mmol/L]和sUA[(308.7±86.9)txmol/L]相比差异无统计学意义(t=0.47、0.90、1.15、1.15、0、0、1.00、0.94,P均〉0.05)。B组瘦素水平的升高与空腹血糖、胰岛素和胰岛素抵抗指数相关(r=0.108、0.146、0.183,P均〈0.05),体质量指数、胰岛素、胰岛素抵抗指数是血清瘦素水平升高的影响因素。结论蒙古族MS患者瘦素水平与空腹血糖、胰岛素和胰岛素抵抗指数相关,瘦素在MS的形成与发展中起重要作用。
[ Abstract] Objective To investigate the differences of leptin (LEP) between Mongol and Han population with metabolic syndrome (MS) and its related factors. Methods According to the diagnostic criterion of MS ,291 people with MS were selected as subjects ,of which, 146 were Han nationality( A group) and 145 were Mongol( B group). Radioimmunoassay kit was used to measure the serum leptin level. At the same time,the indices including weight, height, blood pressure, blood glucose, blood lipid, Serum uric acid (sUA) , insulin (Fins) ,body mass index (BMI) and insulin resistance index (HOMA-IR) were measured. Results The following indices in B group including fasting plasma glucose (FPG) , Low-density lipoprotein cholesterol ( LDL-C ) ,leptin, blood insulin, insulin resistance index were ( 6. 2 ± 1.5 ) mmol/L, ( 3.1 ± O. 8 ) mmol/L , (4. 3 ± 2. 0) p^g/L, ( 22. 4 ± 16. 0 ) mU/L and ( 6. 5 ± 0. 5 ) respectively, significantly differed from that of A group ((6.7-±1.7) mmol/L,(2.7 ~0.7) mmol/L,(3.4_±l.5) pog/L ,(18.8±14.0) mU/L,(4.7-±3.6) respectively ;t = 2. 04,2. 84,3.47,2. 18,4. 82 ;P 〈 0. 01 or P 〈 0. 05 ). There was no significant difference in terms of age( (46. 9 _±9. 8) vs. (46. 3 ± 8.4) ) ,systolic blood pressure (SBP) ( ( 146. 8 ± 17.0) mm Hg vs. ( 149. 1 ± 19. 2) mm Hg), diastolic blood pressure (DBP) ( ( 90. 5 ± 11.6) mm Hg vs. ( 92. 5 ± 13. 1 ) mm ng), BMI ( (27. 4±2. 9) kg/m2 vs. (27.9± 3.2 ) kg/m2 ), total cholesterol ( TC ) ( (5.5 ± 1.0 ) mmol/L vs. ( 5.5 ± 0. 9 ) mmol/L), triacylglycerol (TG) ( ( 2. 3 ± 1.4 ) mmol/L vs. ( 2. 3 ± 1.4 ) mmol/L ), high density lipid cholesterol (HDL-C) ((1.3 ±0.3) mmol/L vs. (1.2 ±0.4) mmol/L),and sUA (((320.7 ±93.6) μmol/L) vs. (308.7 ±86. 9)μmol/L ) between the patients with metabolic syndrome in Mongol population and in Han population(t =0.47,0. 90,1.15,1.15,0,0, 1. 00,0. 94 respectively,P 〉 0.05). The increase of leptin level in the patients with metabolic syndrome in B group was associated with blood glucose, blood insulin and insulin resistance index (r = 0. 108,0. 146,0. 183;P 〈 0. 05 ). BMI, blood insulin and insulin resistance index may be the factors due to the higher of serum leptin levels. Conclusion The serum leptin of patients with metabolic syndrome in Mongol population are correlated with blood glucose, blood insulin and insulin resistance index ,which plays an important role in the development of metabolic syndrome.
出处
《中国综合临床》
2013年第11期1144-1147,共4页
Clinical Medicine of China
基金
内蒙古自治区自然科学基金项目(2010MS1132)
内蒙古卫生厅2010年医疗卫生科研计划项目(2010128)
关键词
代谢综合征
瘦素
胰岛素抵抗指数
Metabolic syndrome
Leptin
Insulin resistance index