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肺癌干细胞的研究进程与展望 被引量:2

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摘要 肺癌是当今世界范围内恶性程度最高的肿瘤之一,而肺癌干细胞已成为肺癌治疗领域中一个十分热门的方向。当前研究表明侧群细胞(side population cell,SP细胞)、CD133、乙醛脱氢酶(acetaldehyde dehydrogenase,ALDH)、CD44是肺癌干细胞的标志物。胚胎发育过程中的信号转导通路,如Wnt通路、Hh(Hedgehog)通路和Notch通路,被认为决定了肺癌干细胞的表型。在肿瘤的复发、转移和耐药方面,肿瘤干细胞起着关键作用,以其标志物和信号转导通路作为靶点来治疗肺癌并提高患者预后是一种新的治疗策略。本文总结了肺癌干细胞当前的研究进展,并展望了未来可能的发展方向。
出处 《癌症进展》 2013年第5期444-448,共5页 Oncology Progress
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