血清反应因子在心血管疾病中的作用
摘要
血清反应因子（serum response factor，SRF）属于MADS转录因子家族的成员之一，是高度保守且广泛表达的转录因子。SRF在成年或发育期的心肌组织中均有表达，主要与下游靶基因启动子上特定DNA序列CArG盒[血清反应元件（SRE）的组成部分，CC（A/T）6GG box]结合，调控抗凋亡或促细胞增殖等基因（如IEGs：c-fos、mcl-1、Egr-1）的表达，对外界因素（如：缺血、缺氧等）刺激表现出快速的基因响应，影响心肌细胞的发育、分化、增殖及凋亡。
出处
《浙江医学》
CAS
2013年第18期1702-1705,共4页
Zhejiang Medical Journal
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