丹红注射液联合低分子肝素治疗不稳定型心绞痛的Meta分析

Unstable angina treated by Danhong injection combined with low molecular weight heparin: a Meta-analysis

目的:评价丹红注射液联合低分子肝素治疗不稳定型心绞痛的疗效。方法:计算机检索PubMed、中国生物医学文献数据库(网络版)、CNKI数据库、万方数据库、重庆维普中文科技期刊全文数据库中有关丹红注射液和低分子肝素治疗不稳定型心绞痛疗效的随机对照试验(RCT),检索时限为建库至2012年11月。对文献质量进行严格评价后,采用Revman5.1软件对纳入的试验结果进行Meta分析。结果:共纳入15篇RCT文献。Meta分析结果显示,心绞痛临床症状疗效评价[OR=5.28,95%CI(3.73,7.47)],心电图改善疗效评价[OR=3.44,95%CI(2.43,4.88)],心绞痛发作频率疗效评价[WMD=-1.86,95%CI(-2.82,-0.89)],3项疗效指标比较,两组差异均有统计学意义。结论:常规治疗基础上,丹红注射液联合低分子肝素治疗不稳定型心绞痛可明显改善患者心绞痛病情,有效控制心绞痛发作。

Objective： To evaluate the effectiveness and safety of Danhong injection combined with low molecular weight heparin in treating unstable angina. Methods： The databases of PubMed, CNKI, CBM, Wanfang and VIP Data were retrieved tbr collecting the randomized controlled trials（RCT） about Danhong injection combined with low molecular weight heparin in treating UA from the date of establishment of the databases to November 2011. After the critical evaluation on the quality of literature. The extracted data was analyzed by RevMen 5.1 software. Results： A total 15 RCT were discovered. Meta-analysis showed that there were statistical differences between two groups in evaluating the symptoms of angina efficacy[ OR =5.28,95% C1（3.73,7.47）], the ECG efficacy[ OR = 3.44,95% CI（2.43,4. 88） ] and the effect of the frequency of angina [ WMD = - 1.86,95% CI（ - 2. 82, -0. 89）]. Conclusion： Meta-analysis manifests that Danhong injection combined with low molecular weightheparin can significantly improve the clinical condition of patients with angina and effectively control angina attacks.