外用去屑中药组方改善头皮屏障功能的临床与实验研究

Clinical observation and study of the efficacy of Traditional Chinese medicine agent for Skin barrier protection and anti-dandruff

目的：观察去屑中药组方对头皮屏障功能及头皮屑的改善情况方法：采用随机、双盲、同身平行、空白剂对照研究，通过临床症状评分及头皮屏障功能测量的方法，比较去屑中药组方使用前中后及随访期中药侧与空白侧头皮屏障功能及头皮屑情况，评估去屑中药组方对于头皮屏障功能的改善及去屑功效。结果：中药侧与空白侧比较，中药侧研究末期（4w）头皮屑总分低于空白侧，具有显著性差异（p〈0．05）。研究末期，随访期（4w，5w）中药侧油脂分泌量低于空白侧，随访期（5w）两侧水分丢失率比较具有显著性差异（p〈0．05）。结论：中药去屑组方能改善中重度头皮屑患者的头皮屏障功能，起效时间在4w-5w，4周后头皮屑总分的临床评价也显示出了中药去屑组方的去屑功效。

Objective To explore the effect of Traditional Chinese medicine agent Methods A double-blind, randomized, own-controlled 5 weeks split-scalp study was conducted. Traditional Chinese medicine agent was applied once daily to half scalp and vehicle-control agent was applied to the other side. Efficacy was based on clinical assessments, survey of skin barrier protection .Results thirty volunteers were recruited and all of them completed a 5- week trial. sebum level and transepidermal water loss were significantly decreased in the fifth week on the treated side, the Dandruff score was significantly decreased in the fourth week. Conclusion The study demonstrates that traditional Chinese medicine agent is safe, and clinically more efficacious than placebo for better condition of scalp-skin barrier and anti-dradruff, The acting time is about 4 to 5 weeks.