营养支持疗法对中晚期肿瘤患者生活质量的影响

Influence of nutrition support therapy on quality of life in patients with advanced tumors

目的 探讨营养支持疗法对中晚期肿瘤患者生活质量的改善效果.方法 选择中晚期肿瘤患者70例,按随机数字表法分为观察组和对照组,每组35例.对照组给予保守疗法,配以普通的流质、半流质或软食；观察组在保守疗法的基础上实施营养支持疗法.比较两组营养和免疫指标、生活质量及症状评分.结果 观察组营养、免疫指标（Alb、BMI和NK）和症状评分（乏力、纳差、失眠、疼痛）较入组时均显著改善（t =7.92、6.98、5.56、7.41、6.47、5.61、4.52,均P＜0.05）,且显著优于对照组（t=4.42、4.10、4.03、6.42、5.60、4.83、4.23,均P＜0.05）.观察组躯体功能、角色功能、情绪功能、认知功能评分及总体评分均显著高于对照组,差异均有统计学意义（t=8.12、6.08、5.12、4.78、4.32,均P＜0.05）.结论 营养支持疗法能明显改善中晚期肿瘤患者的营养状况,缓解症状,提高免疫功能和生活质量,值得临床推广应用.

Objective To investigate the effect of nutrition support therapy on quality of life in patients with advanced tumors.Methods 70 patients with advanced tumors were randomly divided into the observation group and the control group,each group had 35 cases.The control group was given conservative treatment,together with the ordinary liquid,semi-liquid or diet.The observation group was given nutrition support therapy on the basis of conservative therapy.The nutrition and immune index and symptom score,quality of life were compared between the two groups.Results The nutrition,immune indexes （Alb,BMI and NK） and symptom score （malaise,anorexia,insomnia,pain） of the observation group were significantly improved（t =7.92,6.98,5.56,7.41,6.47,5.61,4.52,all P ＜ 0.05）,which were significantly better than those of the control group（t =4.42,4.10,4.03,6.42,5.60,4.83,4.23,all P ＜0.05）.The physical function,role function,emotional function,cognitive function score and total score of the observation group were significantly higher than those of the control group,the differences were statistically significant （t =8.12,6.08,5.12,4.78,4.32,all P ＜ 0.05）.Conclusion Nutrition support therapy can improve the nutritional status of cancer patients in advanced stage,relieve symptoms,improve immune function and quality of life,which is worthy of clinical application.