鼠神经生长因子治疗糖尿病周围神经病变疗效观察

Observation of the effect of mouse nerve growth factor in the treatment of diabetic peripheral neuropathy

目的 分析鼠神经生长因子应用于糖尿病周围神经病变的治疗效果.方法 选择糖尿病周围神经病变患者62例.按照不同治疗方案分为观察组（31例）和对照组（31例）.所有患者均接受糖尿病基础治疗,其中观察组加用鼠神经生长因子,对照组加用甲钴胺,1个疗程后比较两组治疗效果及不良反应发生情况.结果 观察组显效17例,有效12例,总有效率93.55％；对照组显效6例,有效10例,总有效率51.61％,观察组有效率明显高于对照组（x2 =37.917,P＜0.05）.两组治疗后运动传导速度和感觉传导速度均较治疗前改善（t =31.681、19.370、25.409、12.084、21.692、11.308、17.295、9.064,均P＜0.05）,但观察组改善情况明显优于对照组（t =11.075、8.376、9.086、7.319,均P＜0.05）.结论 采用鼠神经生长因子治疗糖尿病周围神经病变对患者临床症状可起到明显缓解效果,能有效改善运动和感觉神经传导速度,且安全性好,值得临床推广.

Objective To analyze the clinical effect of mouse nerve growth factor in the treatment of diabetic peripheral neuropathy.Methods 62 patients with diabetic peripheral neuropathy were selected and divided into the observation group （3 1 cases） and the control group （3 1 cases） by different treatment.Diabetic based treatment was given to all the patients,and mouse nerve growth factor was added in observation group,while mecobalamin added in the control group.The treatment effect and adverse reaction were compared after a course of treatment.Results In the observation group,17 cases were markedly effective,12 cases were effective,and the total effective rate was 93.55 ％.In the control group,6 cases were markedly effective,10 cases were effective,and the total effective rate was 51.61％.The effective rate of the observation group was significantly higher than that of control group（x2 =37.917,P ＜0.05）.The MNCV and SNCV in both two groups were improved after treatment（t =31.681,19.370,25.409,12.084,21.692,11.308,17.295,9.064,all P ＜ 0.05）,but the improvement in observation group was significantly better than that in control group（t =11.075,8.376,9.086,7.319,all P ＜ 0.05）.Conclusion The mouse nerve growth factor in treatment of diabetic peripheral neuropathy could relieve symptoms,improve MNCV and SNCV.It is safe and worthy of clinical application.