血清高密度脂蛋白胆固醇水平检测对肝脏合成功能的评价作用

Clinical value of serum HDL-C in the evaluation of synthetic function of the liver

目的 研究血清高密度脂蛋白胆固醇（HDL-C）水平用于评价肝脏合成功能的价值.方法 用全自动生化分析仪测定对照组30例、肝病组87例血清HDL-C水平,采取t检验分析肝病组87例与对照组30例、肝病组内不同肝病与对照组、以及不同肝病之间血清HDL-C的水平差异.结果 HDL-C水平,对照组（1.28±0.20） mmol/L,肝病组（0.77±0.15）mmol/L,其中肝炎组（0.81±0.13） mmol/L,肝硬化组（0.68±0.14） mmol/L,肝癌组（0.54±0.05） mmol/L.肝病组及肝病组内肝炎、肝硬化、肝癌患者血清HDL-C水平明显低于对照组（t=15.5569、14.2463、45.4393、25.6344,均P＜0.01）；肝病组内肝硬化、肝癌患者血清HDL-C水平明显低于肝炎患者（t=3.6583、16.9057,均P＜0.01）；肝癌患者血清HDL-C水平低于肝硬化患者（t=4.4103,P＜0.01）.结论 肝病患者血清HDL-C水平可以反映肝脏合成功能,血清HDL-C水平越低,肝病患者肝脏合成功能受损越严重.

Objective To evaluate the clinical value of serum high density lipoprotein cholesterol （HDL-C）in the evaluation of synthetic function of the patients with liver diseases.Methods Abbott Aeroset automatic biochemical analyzer was used to detect serum HDL-C level in control group （30 cases） and liver disease group（87 cases）.T test was used to analyze the differences of serum HDL-C level in liver disease group and control group,different liver disease groups and control group,and different liver disease groups.Results HDL-C level was （1.28 ±0.20）mmol/L in the control group,（0.77 ± 0.15）mmol/L in the liver disease group,and （0.81 ± 0.13）mmol/L in the hepatitis group,（0.68 ± 0.14）mmol/L in the liver cirrhosis group,（0.54 ± 0.05）mmol/L in the liver cancer group.The HDL-C level in liver disease group and hepatitis group,liver cirrhosis group,liver cancer group was significantly lower than that in the control group（t =15.5569,14.2463,45.4393,25.6344,all P ＜ 0.01）.The HDL-C level in liver cirrhosis group and liver cancer group was significantly lower than that in hepatitis group （t =3.6583,16.9057,all P ＜ 0.01）.The HDL-C level in liver cancer group was significantly lower than that in liver cirrhosis group（t =4.4103,P ＜ 0.01）.Conclusion Serum HDL-C level can be used to evaluate synthetic function of the liver,the lower of serum HDL-C level,the more serious liver synthesis function is impaired.