苏芬太尼联合地佐辛对开胸手术患者胰岛素抵抗的影响

The effect of sufentanil plus dezocine on insulin resistance of patients underwent thoracotomy

目的 探讨苏芬太尼联合地佐辛对开胸手术患者胰岛素抵抗的影响.方法 将80例开胸手术患者采用随机数字表法分为观察组、对照组各40例,对照组采用苏芬太尼,观察组采用苏芬太尼联合地佐辛镇痛.观察两组镇痛效果和测定胰岛素抵抗指数.结果 两组术后2、12、24 h VAS、Ramsay和BCS评分差异均无统计学意义（均P＞0.05）.两组术后胰岛素抵抗均有明显升高,但对照组较观察组升高更明显（t=5.0233,P＜0.05）.结论 苏芬太尼联合地佐辛与单用苏芬太尼镇痛效果相当,但可以减轻胰岛素抵抗.

Objective To study the effect of sufentanil plus dezocine on insulin resistance of patients underwent thoracotomy.Methods 80 patients underwent thoracotomy were randomly divided into the observation group （n =40 cases） and the control group （n =40 cases）.The patients in the control group were anesthetized through sufentanil,while the patients in the observation group were anesthetized through sufentanil plus dezocine.The analgesic effect and insulin resistance index were compared.Results There wasn＇t significant difference between two groups in VAS,Ramsay and BCS 2,12 and 24 hours after operation （all P ＞ 0.05）.Insulin resistance index in both two groups was increased after operation and it in the control group was higher than that in the observation group（t =5.0233,P＜0.05）.Conclusion The analgesic.effect of sufentanil plus zuoxin is the same as sufentanil alone,but can reduce insulin resistance.