稳心颗粒联合卡维地洛治疗心力衰竭合并频发室性早搏临床观察

Clinical observation of Wenxin granule combined with carvedilol in treating heart failure with frequent ventricular premature beat

目的探讨稳心颗粒联合卡维地洛治疗慢性心力衰竭合并频发室性早搏的临床疗效。方法将慢性心力衰竭合并频发室性早搏入选患者72例随机分为治疗组(37例)和对照组(35例)。对照组进行心力衰竭综合治疗加卡维地洛,治疗组在对照组治疗方案基础上加用稳心颗粒,两组疗程均为8周。结果以24 h动态心电图检查比较在控制室性心律失常中,治疗组总有效率(36/37,97.3%)优于对照组(25/35,71.4%),差异有统计学意义(P<0.01)。在改善心功能比较中,两组心功能均较治疗前有明显改善,差异有统计学意义(P<0.01),但两组治疗后比较,差异无统计学意义(P>0.05)。结论稳心颗粒联合卡维地洛治疗慢性心力衰竭合并频发室性早搏安全、有效,控制室性心律失常疗效更加突出,值得临床推广应用。

Objective To explore the clinical efficacy of Wenxin granule combined carvedilol in treating patients with chronic heart failure（CHF）combined frequent ventricular premature beat（FVPB）. Methods 72 patients with CHF combined with FVPB were selected and divided randomly into the treatment group （n=37） and the control group （n=35）. The control group was with comprehensive treatment of CHF combined with carvedilol ,while the treatment group was added with Wenxin granule on the basis of control group. Course of treatment in both groups were 8 weeks. Results The therapeutic effect of ventricular ar- rhythmia was analyzed by 24-hour dynamic electrocardiographic examination. The total effective rate in treatment group was prior to that in control group （36/37 vs. 25/35,97.3% vs. 71.4%）, and the difference had statistical significance （P〈0.01）. The cardiac function after treatment in both groups were improved more obviously than that before treatment with statistically significant difference （P〈0.01）, but the comparison after the treatment in both groups had no statistical significance （P〉0.05）. Conclusion Wenx- in granule combined with carvedilol is safe and effective in the treatment of CHF with FVPB and has obviously therapeutic effect in controlling ventricular arrhythmias. It is worthy of clinical promotion.