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DYNAMICS BEHAVIOR OF MUTATION DURING REPRODUCTION ON HIV-1 DRUG RESISTANCE

DYNAMICS BEHAVIOR OF MUTATION DURING REPRODUCTION ON HIV-1 DRUG RESISTANCE
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摘要 To study the transition dynamics of resistant-type human immunodeficiency virus 1 (HIV-1) in highly active antiretroviral therapy (HAART) and the affect of neutral mutation in the evolution of HIV-1, a mathematical model is proposed when mutation occurs mainly during reproduction. The derived results show that the resistant-type will certainly colonize in patients once mutation occurs. Furthermore, a neutral mutation is closely related to the colonized pattern of resistant-type HIV-1 quasispecies and there are some changes in the pattern of transmission dynamics when mutation occurs mainly during reproduction or in the absence of reproduction, which may lead to significant strategies for predicting or checking HIV-1 drug resistance in HAART.
出处 《International Journal of Biomathematics》 2013年第3期109-120,共12页 生物数学学报(英文版)
基金 Acknowledgments This work is supported by the National Natural Science Fund of P. R. China (No. 11271369) and the Natural Science Foundation Project of CQ CSTC (2010BB5020).
关键词 Human immunodeficiency virus 1 mutation during reproduction drug resistance highly active antiretroviral therapy stability. HIV-1 中性突变 耐药性 动力学行为 人类免疫缺陷病毒 逆转录病毒 动力学模式 数学模型
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