急性缺血性脑卒中CISS分型与危险因素相关性分析

Analysis of the Relationship between Chinese Ischemic Stroke Subclassification and Risk Factors of Acute Cerebral Ischemic Stroke

探讨急性缺血性脑卒中CISS分型与不同危险因素的关系。回顾性分析连续登记的急性缺血性脑梗塞患者,记录其危险因素,并按CISS分型标准将急性缺血性脑卒中分为5种类型并分析相关因素对其发生风险的影响。结果显示在纳入标准的212例急性缺血性脑卒中患者中,大动脉粥样硬化型99例(46.7%)、心源性卒中型35例(16.5%)、穿支动脉疾病45例(21.2%)、其他病因型5例(2.4%)、病因不确定型28例(13.2%)。吸烟者、患高血压病、冠心病、房颤者在5亚型间比例差异具有统计学意义(P<0.05)。相关和回归分析显示冠心病、房颤与心源性卒中亚型有正相关性(β=1.34、2.206,P<0.05),高血压病与穿支动脉疾病亚型有相关性,为正相关性(β=1.074,P<0.05)。不同类型缺血性脑卒中与不同的危险因素有关,房颤、冠心病是心源性卒中亚型的危险因素,高血压病是穿支动脉疾病亚型的危险因素。

This is to explore the relationships between Chinese Ischemie Stroke Subclassification （CISS） and risk factors of acute cerebral cerebral ischemic stroke. The clinical data of patients with acute cerebral infarction （ACI） were analyzed retrospectively. The diagnoses were established by imaging and other etiological examinations. The subtypes of patients were identified according to CISS criteria, and their major risk factors were investigated and analyzed. Our study cohort comprised included 212 patients with acute ischemic stroke. There were 99 patients with large artery atherosclerotic cerebral infarction （LAA）, 35 with cardiogenic stroke （CS）, 45 with penetrating artery disease （PAD）, 5 with stroke of other etiologies （OE）, and 28 with stroke of undetermined etiologies （UE）. There are some statistically significant differ- ences in the proportion of the smokers, hypertension, coronary heart disease and atrial fibrillation among these subtypes. Regression analysis showed that coronary heart disease and atrial fibrillation were positive correlation with CS （t~~ 1.34, 2. 206, P^0.05）, hypertension was positive correlation with PAD （9--1. 074, P^0.05）. Different stroke subtypes in etiology could be associated with different risk factors, Coronary heart disease and atrial fibrillation were the risk factors for CS, and hypertension was a risk factor for PAD.