单中心ICU鲍曼不动杆菌感染的流行病学分析

Single Center Epidemiological Analysis of Acinetobacter Baumannii Infection in ICU

通过对重症加强护理病房（intensive care unit,ICU）中鲍曼不动杆菌（Aeineto bacter baumannii,ABA）的流行病学调查,探讨耐药ABA的流行病学特点及防范措施.回顾性分析我院重症医学科2010年～2012年间收治的患者培养出的ABA的菌株数、耐药情况、抗生素种类、侵袭性操作、呼吸机使用等情况.采用统计图表分析,同时用双元Logistic回归分析每个因素对该菌感染的影响.结果显示,ABA的检出率有逐年升高趋势；ICU中的耐药性比普通病房高；ABA感染与气管镜等呼吸道侵袭性操作次数、呼吸机通气时间、气管内置管时间、碳青霉烯类抗菌药使用时间有关,而与是否联合使用多种抗生素以及住院天数无显著关系.实验表明ABA引起的感染有增多趋势,耐药性逐渐增强,应逐渐减少上机时间,减少侵袭性气道操作,减少碳青霉烯类广谱抗生素的使用时间.

To investigate the prevention measures of resistant Acineto bacter baumannii （ABA） infection with the epidemio- logical survey in ICU. We make a retrospective study of ABA strains isolated from ICU patients during 2010~2012 and analysis of antibiotic resistance, the kinds of antibiotics, invasive operation, machine ventilation ,etc. The data analysis was performed for epidemiological trends of bacteria with statistical chart, and the impact of each factor on the bacterial infection with binary Logistic regression analysis. Results show us as： The incidence of ABA infection is increasing year by year. The resistance level of Acinetobacter baumannii from ICU continues higher than that from public units. The incidence of ABA infection was associated with ventilation, bronchoscopy, invasive operation and using carbapenem except for the hospital days and combined using of antibiotics. Therefore, ABA infections is increasing daily with powerful resistance. Enough attention should be given to it. To prevention from ABA infection, it is important to gradually reduce the ventila- tion time, reduce invasive airway operation, reduce the use of carbapenem.