摘要
目的初步探讨氟尿嘧啶羧甲基壳聚糖(FU-CMCS)微球制备工艺及体外释药特性。方法以羧甲基壳聚糖(CMCS)为载体材料,采用乳化交联法制备氟尿嘧啶羧甲基壳聚糖(FU-CMCS)微球。考察投药方式、交联剂、超声乳化作用等因素对微球粒径、体外释药的影响。结果该方法制得FU-CMCS微球平均粒径1.6μm,球形圆整、流动性良好,人工肠液释药长达15d。结论该制备工艺方法简单,制得FU-CMCS微球粒径小,分布窄,在体外具有缓释作用。
OBJECTIVE To discusse the microsphere preparation technology of the FU-CMCS and the charac- teristics of external drug release. METHODS Based on the carrier material of CMCS, emulsion crosslinking was a- dopted to manufacture the FU-CMCS. The effeet of drug delivery way,crosslinking agent and the effect of ultrasonic emulsification on the microphere's paticle size distribution and in vitro drug release were studied. RESULTS The mierosphere's average particle size was 1.6 μm, with rounding ball and good liquidity, the time of the drug release of its artificial intestinal juice was long to 15 days. CONCLUSION This technology is simple with small, mierosphere' s particle size and narrow distribution, which owns sustained-release effect in virto.
出处
《海峡药学》
2013年第9期26-28,共3页
Strait Pharmaceutical Journal
基金
福建医科大学青年教师科研基金资助项目(FJGXQ04024)
关键词
氟尿嘧啶
羧甲基壳聚糖
微球
体外释放
Fluorouracol
Carboxymethyl chitosan
Microspheres
In vitro release