钛基/涂层型羟基磷灰石功能梯度生物材料研究进展

Research Progress of Titanium Matrix / Coating Hydroxyapatite Functionally Graded Biomaterials

钛及钛合金是常用的医用生物材料,虽具有良好的生物相容性,但缺乏骨诱导能力,而羟基磷灰石(HA)有良好的生物活性能诱导骨生长,钛基/涂层型HA功能梯度生物材料(FGM)为解决二者的结合提供了新的思路.钛基/涂层型HA FGM其设计主要分为组成成分的梯度设计与孔隙梯度变化2种,通过基体与涂层表面之间形成逐渐过渡的功能梯度,能显著提高材料的机械强度和生物骨诱导能力.概述其设计、制备及性能评价等最新研究,为临床运用提供参考.

Titanium and titanium alloys are comn^nly used medical biomaterials, which lack osteoinducfive capacity despite good biocompatibility. But hydroxyapatite（HA） has good biological activity being capable of inducing bone growth. Titanium-based coating HA functionally graded biomaterial（FGM） provides new ideas to solve the combination of both. The design of titanium based coating type HA FGM includes the gra- dient design of the components and the pore gradient change; and the functional gradient with a gradual transition is formed between the base body and the coating surface, which can significantly improve the me- chanical strength and biological osteoinductive capability. This article outlines the design, preparation and performance evaluation of the latest research to provide reference for clinical use.