6-甲基香豆素分子印迹聚合物微球与共聚微球的制备与研究

Preparation and study of 6-methylcoumarin molecular imprinting polymer microspheres and copolymer microspheres

为了获得6-甲基香豆素分子印迹聚合物微球与共聚微球,以6-甲基香豆素为模板分子,首选采用分散聚合方法制得的纳米级聚苯乙烯微球(PS)为种球,通过单步溶胀聚合法在水相中制备了单分散分子印迹聚合物微球(MIPs);然后选用甲醇/水极性混合溶剂作反应介质,以聚乙烯吡咯烷酮(PVP)为分散剂,偶氮二异丁腈(AIBN)为引发剂,采用分散共聚的方法制备微米级单分散新型苯乙烯/6-甲基香豆素微球;通过扫描电镜、紫外光谱和红外光谱等手段对两种微球进行了表征。研究表明:采用共聚法得到的微球单分散性良好,无破损、无缺陷,非常光滑,微球其平均粒径为450—500 nm左右;所制得的MIPs平均粒径为200—300 nm,表面粗糙,具有一定孔径,特异吸附性能良好;当甲醇和水比例为80∶20时,单体配比为100∶2时,可以得到粒径分布均匀的共聚微球。

In order to obtain 6-methylcoumarin microspheres,6-methylcoumarin serves as template method, the polystyrene microspheres （PS） as the prepared for monodisperse molecularly imprinted mixed solvent is used as reaction medium molecular imprinting polymer mlcrospheres and copolymer molecule, first of all to the nanoseale dispersion polymerization ball, by single-step swelling polymerization in aqueous phase was polymer microspheres （MIPs）; And then the methanol/water polarity, with polyvinylpyrrolidone （ PVP ） as dispersant, azodiisobutyronitrile（AIBN） as initiator, and the method copolymerization preparation of micron grade / 6-methyl styrene monodisperse new coumarin microspheres is adopted;By scanning electron microscopy , ultraviolet spectrum and infrared spectrum methods for two kinds of microspheres have been characterized, and studies have shown that ： those obtained by copolymerization of microspheres single dispersivity are good, without damage, without defects and very smooth. Microspheres with an average particle size is about 450--500 nm, MIPs made by an average particle size of 200--200 nm, rough surface, have a certain pore size, and specific adsorption performance is good; When the methanol and water ratio of 80： 20, the monomer ratio of 100： 2 can get uniform particle size distribution of copolymer microspheres.