动态胰岛素泵对2型糖尿病患者血糖波动控制的效果

Sensor-Augmented Insulin-Pump in Regulation of the Glucose Fluctuations of Patients with Type 2 Diabetes Mellitus

目的观察动态胰岛素泵对2型糖尿病患者血糖波动控制的效果。方法将我院内分泌科2010年2月—2012年2月住院44例2型糖尿病患者随机分成2组,分别接受动态血糖监测、持续皮下胰岛素输注(CSⅡ)、Care Link糖尿病管理软件联合治疗即3C治疗和CSⅡ治疗,每组22例。比较两组血糖波动控制的效果。结果 3C治疗组24 h平均血糖(MBG)、血糖波动系数(SDBG)、平均血糖波动幅度(MAGE)、日间血糖平均绝对差(MODD)均优于CSⅡ治疗组(P<0.05),而两组间平均血糖波动次数(NGE)、血糖<3.9 mmol/L的曲线下面积(AUC3.9)差异无显著性(P>0.05)。结论在血糖控制不理想的2型糖尿病患者中,3C治疗可以在不增加低血糖风险的情况下使血糖快速、平稳达标。

Objective To observe sensor-augmented insulin-pump in regulation of the glucose fluctuations of patients with type 2 diabetes mellitus （T2DM）. Methods A total of 44 patients with T2DM in our hospital during February 2010 and February 2012 were randomly divided into two groups. Group A （n = 22） accepted continuous glucose monitoring system （CGMS） , continuous subcutaneous insulin infusion （CSII） combined with CareLink therapy（3C） , and group B （ n = 22） was given CSII therapy. The efficacy of the two groups in regulation of the glucose fluctuations was compared. Results The values of mean blood glucose （MBG） , standard deviation of blood glucose （SDBG） , mean amplitude of glycemic excursions （MAGE） and absolute means of daily differences （MODD） after treatment for 24 h in the two groups showed significant differences （ P 〈 0.05 ） ; the values in effective blood glucose fluctuations in frequency （NGE） and area under curve （AUC） 〈 3.9 mmol/L showed no significant differences （P 〉 0.05）. Conclusion Patients with T2DM, whose blood glucose are not controled well, may accept 3C therapy, which may rapidly and stably reduce blood glucose fluctuations without increasing hypoglycemia risk.