摘要
分析2型糖尿病糖耐量减低(IGT)一级亲属经1年生活方式干预后不同转归者的临床特点.160例IGT者中,56例(35.0%)转为正常糖耐量(NGT),44例(27.5%)发生2型糖尿病,60例(37.5%)仍为IGT.基线时3组BMI、胰岛素抵抗指数、空腹胰岛素无差异;但基线早时相胰岛素分泌在NGT组>IGT组>糖尿病组,基线糖化血红蛋白则相反.转为2型糖尿病组的基线胰岛素曲线下面积最高,基线肿瘤坏死因子-α最低.2型糖尿病的IGT一级亲属经1年生活方式干预后不同转归者存在明显差异.
To evaluate the characteristics of impaired glucose tolerance(IGT) patients with different outcomes after one-year lifestyle intervention.A total of 160 IGT patients in first degree relatives of type 2diabetes mellitus(T2DM)completed the study.Among them,56 (35.0%) converted into normal glucose tolerance (NGT),44 (27.5%) progressed to T2DM and 60 (37.5%) stood still.Baseline BMI,homeostasis model assessment of insulin resistance(HOMA-IR) and fasting serum insulin were not different among three groups.However,basal Δ'I30/ΔG30 was greater in NGT group than IGT and T2DM groups.And hemoglobin A1c was greater in T2DM group than NGT and IGT groups.T2DM patients had a largest area of insulin under curve,but a lowest level of tumor necrosis factor-α.Therefore IGT patients with different outcomes after one-year intervention have different characteristics.
出处
《中华全科医师杂志》
2013年第10期826-829,共4页
Chinese Journal of General Practitioners
基金
国家重点基础研究发展计划(973计划)支持项目(2009CB523003)
天津市自然科学基金重点项目(13JCZDJC30500)