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霉酚酸酯治疗原发小血管炎的疗效观察 被引量:3

Efficacy of mycophenolate mofetil treatment for primary small vessel vasculitis
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摘要 目的观察霉酚酸酯和间断环磷酰胺静脉冲击治疗原发小血管炎的疗效、不良反应和复发率。方法我院2010年1月至2011年1月收治的25例原发小血管炎患者随机分为霉酚酸酯组(MMF组)12例,间断环磷酰胺静脉冲击组(CTX组)13例。比较两组病情缓解率、不良反应发生情况、患者肾功能变化、复发情况等。结果 MMF组患者缓解率、肾功能恢复率、ANCA变化转阴率均明显优于CTX组(P<0.05);MMF组不良反应发生率低于CTX组(25.0%vs.38.6%,P<0.05)。结论与传统间断环磷酰胺静脉冲击治疗相比,采用霉酚酸酯治疗原发小血管炎,缓解率更高,复发率更低,且肾功能恢复情况较为理想。 Objective To investigate the efficacy,adverse effects and the recurrent rate of mycophenolate mofetil and cyclophosphamide treatment for primary small vessel vasculitis.Methods 25 cases with primary small vessel vasculitis in our hospital from January 2010 to January 2011 were randomly divided into mycophenolate mofetil group(MMF group,n=12) and cyclophosphamide group(CTX group,n=13).The remission rate,side effects,change of renal function and the recurrence of the patients were compared.Results The remission rate,recovery rate of renal function,changes in ANCA negative rate in MMF group were obviously better than those of CTX group(P0.05); the incidence of adverse reaction of MMF group was lower than that of CTX group(25.0% vs.38.6%,P0.05).Conclusion Compared with traditional cyclophosphamide treatment,mycophenolate mofetil has higher remission rate,lower recurrence rate,and the recovery of renal function is better in treating primary small vasculitis.
作者 许化恒
出处 《实用药物与临床》 CAS 2013年第9期870-872,共3页 Practical Pharmacy and Clinical Remedies
关键词 霉酚酸酯 环磷酰胺 原发小血管炎 肾损害 Mycophenolate mofetil Cyclophosphamide Primary small vessel vasculitis Renal damage
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参考文献8

  • 1Klemmer PJ,Chalermskulrat W,Reif MS,et al.Plasmapheresis therapy for diffuse alveolar hemorrhage in patients with small-vessel vasculitis[J].Am J Kidney Dis,2003,42(6):1149-1153.
  • 2Hu W,Liu C,Xie H,et al.Mycophenolate mofetil versus cyclophosphamide for inducing remission of ANCA vasculitis with moderate renal involvement[J].Nephrol Dial Transplant,2008,23(4):1307-1312.
  • 3Silva F,Specks U,Kalra S,et al.Mycophenolate mofetil for induction and maintenance of remission in microscopic polyangiitis with mild to moderate renal involvement-a prospective,open-label pilot trial[J].Clin J Am Soc Nephrol,2010,5(3):445-453.
  • 4Holle JU,Wieczorek S,Gross WL.The future of ANCA-associated vasculi-tis[J].Rheum Dis Clin North Am,2010,36(3):609-621.
  • 5Stone JH,Merkel PA,Spiera R,et al.Rituximab versus cyclophosphamide for ANCA-associated vasculitis[J].N Engl J Med,2010,363(3):221-232.
  • 6于峰,陈旻,赵明辉.免疫抑制剂在原发性小血管炎治疗中的应用[J].中国实用内科杂志,2008,28(5):331-334. 被引量:11
  • 7薛超,卜昆鹏,罗佐杰,廖蕴华.激素加环磷酰胺治疗原发ANCA相关性小血管炎肾损害的临床观察[J].广西医科大学学报,2011,28(2):256-258. 被引量:7
  • 8赵明辉.抗中性粒细胞胞质抗体相关小血管炎诊断和治疗中的问题与对策[J].中华风湿病学杂志,2009,13(4):217-219. 被引量:4

二级参考文献39

  • 1胡伟新,刘春蓓,谢红浪,王庆文,陈惠萍,刘志红,黎磊石.霉酚酸酯与环磷酰胺治疗ANCA相关血管炎的临床对照研究[J].肾脏病与透析肾移植杂志,2005,14(6):501-507. 被引量:27
  • 2Haubitz M, Schellong S, Gobel U,et al. Intravenous pulse administration of cyclophosphamide versus daily oral treatment in patients with antineutrophil cytoplasmic antibody-associated vasculitis and renal involvement : a prospective, randomized study [ J ]. Arthritis Rheum ,1998,41 (10) :1835 - 1844.
  • 3De Groot K,Jayne CRW,Tesar V,et al. Randomised controlled trial of daily oral versus pulse cyclophosphamide for induction of remission in ANCA-associated systemic vasculitis[ J ]. Kidney Blood Press Res,2005,28:195.
  • 4Stassen PM, Cohen Tervaert JW, Stegeman CA. Induction of remission in active ANCA-associated vasculitis with mycophenolate mofetil in patients who cannot be treated with cyclophosphamide[ J]. Ann Rheum Dis,2007,66 ( 6 ) :798 - 802.
  • 5Guillevin L, Cohen P,Mahr A, et al. Treatment of polyarteritis nodosa and microscopic polyangiitis with poor prognosis factors: a prospective trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in sixty-five patients [ J ]. Arthritis Rheum, 2003,49( 1 ) :93 - 100.
  • 6Jayne D, Rasmussen N, Andrassy K, et al. A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies [ J ]. N Engl J Med, 2003,349 ( 1 ) : 36 -44.
  • 7Sanders JS, Slot MC, Stegeman CA. Maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies[J]. N Engl J Med,2003,349(21 ) :2072 -2073.
  • 8Nowack R, Gobel U, Klooker P, et al. Mycophenolate mofetil for maintenance therapy of Wegener's granulomatosis and microscopic polyangiitis: a pilot study in 11 patients with renal involvement [J]. J Am Soc Nephrol,1999,10(9) :1965 - 1971.
  • 9Langford CA,Talar-Williams C, Sneller MC. Mycophenolate mofetil for remission maintenance in the treatment of Wegener's granulomatosis[ J]. Arthritis Rheum,2004,51 (2) :278 - 283.
  • 10Metzler C, Fink C, Lamprecht P, et al. Maintenance of remission with leflunomide in Wegener's granulomatosis [ J ]. Rheumatology (Oxford) ,2004,43 ( 3 ) :315 - 320.

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