两种血清学指标联合检测对Ⅰ型糖尿病肾病早期诊断的临床意义

Clinical significance of combined detection of two serum indicators for the early diagnosis ofⅠtype diabetic nephropathy

目的探讨血清中糖化血红蛋白和胱抑素-C的联合检测对Ⅰ型糖尿病肾病早期诊断的价值。方法选择2012年1～11月在宁强县天津医院住院并确诊为Ⅰ型糖尿病肾病患者100例(实验组)和同期健康体检者100例(对照组),同时检测对象血清中糖化血红蛋白和胱抑素-C的含量。结果Ⅰ型糖尿病肾病各期患者血清中糖化血红蛋白和胱抑素-C浓度水平与对照组相比明显升高,差异有统计学意义(P<0.05或P<0.01)。不同程度Ⅰ型糖尿病肾病血清中糖化血红蛋白和胱抑素-C浓度水平均明显增高,趋势呈正相关,差异有统计学意义(P<0.05)。结论血清中糖化血红蛋白和胱抑素-C测定有助于Ⅰ型糖尿病肾病早期诊断,能为临床医生提供有价值的诊断指导依据。

Objective To explore the clinical significance of combined detection of serum glycosylated hemoglobin A1c（HbA1c）and cystatin C（Cys-C）for the early diagnosis ofⅠtype diabetic nephropathy（DN）.Methods 100cases of patients withⅠtype DN,treated in this hospital from Jan.to Nov.2012,were enrolled as experiment group,and 100cases of healthy subjects were enrolled as control group.Serum levels of HbA1cand Cys-C were detected.Results Serum levels of HbA1cand Cys-C in experiment group was higher than control group（P0.05or P0.01）.Serum levels of HbA1cand Cys-C increased with the increasing of disease severity significantly（P 0.05）.Conclusion Combined detection of serum HbA1cand Cys-C might be helpful for the early diagnosis ofⅠ type DN,and could provide valuable diagnostic guidance for clinical doctors.