摘要
Objective: Neurons in the cochlear nucleus show different response patterns to the short tone bursts. Because of the limitations of animal experiments, it is hard to explore the principle. Therefore, using a model to simulate CN neurons will be a feasible way. Methods: Based on the initial model mentioned in the previous study, we proposed an improved CN model in MATLAB R2012b. Results: By modifying the parameters of the model we found the interchanges among "primary-like", "chopper",and "onset" response patterns. Furthermore, we simulated the "pauser" response pattern by adding an extra input in our model. Conclusion: The results indicate that the synaptic integrations and the input modes can give rise to different characteristics of CN neurons, which eventually determine the response patterns of CN neurons.
Objective： Neurons in the cochlear nucleus show different response patterns to the short tone bursts. Because of the limitations of animal experiments, it is hard to explore the principle. Therefore, using a model to simulate CN neurons will be a feasible way. Methods： Based on the initial model mentioned in the previous study, we proposed an improved CN model in MATLAB R2012b. Results： By modifying the parameters of the model we found the interchanges among ＂primary-like＂, ＂chopper＂, and ＂onset＂ response patterns. Furthermore, we simulated the ＂pauser＂ response pattern by adding an extra input in our model. Conclusion： The results indicate that the synaptic integrations and the input modes can give rise to different characteristics of CN neurons, which eventually determine the response patterns of CN neurons.
基金
National Natural Science Foundation of China
grant number:31171059
