银屑病合并IgA肾病的临床特征分析探讨

Analysis of Clinical Features of Patients with IgA Nephropathy Associated with Psoriasis Vulgaris

目的:分析银屑病合并IgA肾病的临床表现、免疫学特点和肾脏病理特点。方法:回顾性分析5例2006年1月至2012年12月在本院诊治的银屑病合并IgAN患者的临床表现、实验室指标和肾脏病理特点。结果:多见于男性,其中男4例、女1例,平均年龄50.8岁;5例患者均为寻常型银屑病,发生肾损害时银屑病病程为1-30年;在银屑病发病后平均28月发现肾脏损害,以无症状性镜下血尿和蛋白尿起病1例、以发作性肉眼血尿起病2例、以肾病综合征起病1例、以慢性肾炎综合征起病1例;5例患者均无严重肾脏病理表现,光镜下表现为轻度系膜细胞增生和系膜基质稍增多。结论:银屑病合并IgAN多见于男性患者,临床主要表现为尿检异常或肾病综合征、肾小管功能受损,肾组织光镜下多见节段系膜增生性病变。

Objective： To investigate the clinical and pathological features in patients with [gA nephropathy（[gAN） associ- ated with psoriasis vulgaris. Method： 5 patients diagnosed as IgA nephropathy associated with psoriasis vuigaris in our hospital from January 2006 to December 2012 were included in the study, and the clinical manifestations, laboratory parameters and re- nal pathological features were analyzed. Result： There were four males and one female （more common in males） , mean age 50.8 years. 5 patients were psoriasis vulgaris, and the duration between psoriasis and nephropathy was 1-30 years, the mean history of renal lesion was 28 months;1 case show asymptamatic hematuria and （or） proteinuria,and ,2 cases gross hematufia, 1 case nephrotic syndrome and 1 case chronic nephritic syndrome,5 cases all showed no severe pathological manifestation and showed mild to moderate mesangal proliferative lesions and mesangial matrix increase slightly from light microscope. Conclu- sion： IgAN patients with psoirasis existed more common in males, and the patients presented hematuria and （or） proteinuria nephrotic syndrome, Impaired renal tubular function,while showed mesangal proliferative lesions from light microscope.