磷酸肌酸联合参麦治疗新生儿窒息后心肌损害的疗效观察

Observation on the Effects of Phosphocreatine Combined with Shenmai on Cardiac Damage Secondary to Neonatal Asphyxia

目的:探讨磷酸肌酸联合参麦治疗新生儿窒息后心肌损害的临床疗效,以及对心功能的影响。方法:收集80例新生儿窒息后心肌损害患儿,采用随机数字的方法分为观察组和对照组各40例,均给予综合治疗,在此基础上对照组加用果糖二磷酸钠和维生素C,观察组加用磷酸肌酸钠和参麦注射液,疗程均为7d。观察两组患儿临床症状及体征、心电图、心肌酶谱、肌钙蛋白及左心功能等变化。结果:观察组患儿临床总有效率为95.00%,明显高于对照72.50%,差异存在统计学意义(P<0.05)。两组患儿治疗前血清CK-MB和cTnI水平,以及LVEF和SF比较,差异无统计学意义(P>0.05);疗程结束后,两组患而血清CK-MB和cTnI水平,以及LVEF和SF均得到改善P<0.05),但是观察组变化幅度更大P<0.05)。结论:磷酸肌酸联合参麦治疗新生儿窒息后心肌损害临床疗效确切、促进心肌恢复、保护心脏功能、改善心肌能量代谢,值得临床推广应用。

Objective： To investigate the clinical therapeutic effects of phosphocreatine combined with Shenmai on cardiac damage secondary to neonatal asphyxia and the influence on heart function. Method： 80 sick infants with cardiac damage sec- ondary to neonatal asphyxia were collected and randorrdy divided into observation group and control group, 40 infants in each group; all the infants were given with combined modality therapy, additionally, the control group was supplemented with fruc- tose diphosphate sodium and vitamin C, while the observation group was supplemented with phosphocreatine and Sbenmai injec- tion, and the course of treatments of both groups were 7 days. The changes in the clinical symptom, physical sign, ECG, myo- cardial zymogram, treponin, and left heart function and so on of the infants of the two groups were observed. Resttlt： The clini- cal total effective rate of the infants of the observation group was 95.00%, significantly higher than that of the control group （ 72.50% ）, and the difference was statistically significant （ P〈O. 05 ）. The differences in pre-therapy serum CK-MB and cTnI levels, LVEF, and SF between the two groups were statistically insignificant （P〉0.05） ; After the treatments, the serum CK- MB and cTnI levels, LVEF, and SF of both groups were improved （P〈O. O5）, but those of the observation group were im- proved more significantly （ P〈O. 05 ）. Conclusion： Phosphocreatine combined with Sbenmai in treatment of cardiac damage secondary to neonatal asphyxia is effective, can promote myocardial recovery, protect heart function and improve myocardial en- ergy metabolism, and consequently is worthy of clinical application.