骨折患者中医证型与血栓前状态分子标志物检测指标的相关性研究

Relationship Study of TCM Syndrome and Prethrombotic State Molecular Marker in Patients with Fractures

目的揭示血栓前期状态分子标志物检测指标与中医证型之间的相关性。方法对196例患者进行临床观察,并且按病例纳入标准观察患者的四诊资料及血栓前状态分子标志物检测指标填入证型调查表,并根据诊断标准进行证型的归纳和确定,进而将调查表所得数据进行统计学分析。结果骨折患者的血栓前状态的发病率为32.14%,其中以气虚血瘀证为主;气虚血瘀证PT指标与其他各证型差异有统计学意义(P<0.05);气虚血瘀证以及气滞血瘀证DD指标明显高于正常指标,且分别与湿热内蕴证、积瘀化热证差异有统计学意义(P<0.05);而气虚血瘀证与气滞血瘀证之间比较,差异无统计学意义(P>0.05);湿热内蕴证ESR指标与其他各证型差异有统计学意义(P<0.05)。结论骨折患者中医证型与血栓前状态分子标志物检测指标的存在明显的相关性;气虚血瘀证骨折患者是发生血栓前状态的主要证型,同时有转化成血栓性疾病的风险,故对该型骨折患者应该重点检测。

Objective：To investigate the relationship between TCM syndrome and prethrombotic state （PTS）molecular markers in patients with fractures.Methods：196 patients with fractures who met inclusion criteria and treated operatively in our institute were analyzed.The syndrome type were determined according to the diagnostic criteria by statistical study of 4 diagnostic methods information and PTS molecular markers in the questionnaire.Results：The incidence rate of PTS in patients with fractures was 32.14％,and the dominant syndrome type was the syndrome of blood stasis due to qi deficiency （BSQD）.The PT indices were statistically significant different between group BSQD and the others （P＜0.05）.The DD index in group BSQD and syndrome of qi stagnation and blood stasis （QSBS） were significant higher than those in the other two groups （P＜ 0.05）.But there were no significant diffrerences between group BSQD and QSBS（P＞0.05）.The ESR indices were statistically significant different between group syndrome of damp-heat and others （P＜ 0.05）.Conclusion：There is a positive correlation between TCM syndrome and PTS molecular markers.The dominant syndrome type is the syndrome of blood stasis due to qi deficiency （BSQD） in patients with PTS,who has the potential risk of progressing to thrombosis disease.Intensive monitoring should be taken for patients with fractures and the syndrome of BSQD.