脑源性神经营养因子基因Val66Met多态性与重性抑郁障碍患者认知功能的关系

Relationship between brain-derived neurotrophic factor gene Val66Met polymorphism and cognitive function in patients with major depressive disorder

目的:探讨脑源性神经营养因子(BDNF)基因Val66Met多态性与重性抑郁障碍认知功能的关系。方法:对100例重性抑郁障碍患者进行认知功能测验和事件相关电位P300检查,同时检测BDNF基因多态性。结果:Val/Val基因型患者大部分认知测验成绩优于Met/Met基因型,差异均有统计学意义(P均<0.01);Met/Met基因型患者P3潜伏期(LATP3)长于Val/Val基因型[分别(304.3±11.8)ms和(293.3±15.7)ms],P3波幅(AMPP3)低于Val/Val基因型[分别(5.9±1.9)μV和(7.4±2.1)μV],差异均有统计学意义(P<0.05或P<0.01)。结论:BDNF基因Val66Met多态性可能与重性抑郁障碍患者认知功能损害有关。

Objective： To investigate relationship between brain-derived neurotrophic factor （BDNF） gene Va166Met polymorphism and cognitive function in patients with major depressive disorder. Method：One hundred patients with major depressive disorder were assessed by a series of cognitive function tests and event- related potential P300 ; BDNF gene polymorphism was also detected. Results： Most achievements of cognitive function tests were significantly better in ones with Val/Val genotype than in ones with Met/Met genotype（ P 〈 0.01 ）;P3 latency（ LATP3 ） was longer in ones with Met/Met genotype than in ones with Val/Val genotype [ （304.3 ± 11.8 ） ms vs. （293.3 ± 15.7 ） ms ] , P3 amplitude （ AMPP3 ） was in the opposite direction [ （ 5.9 ＋ ±1.9）μV vs. （7.4 ＋2.1） μV] （P〈0.05 or P〈0.01）. Conclusion：BDNF gene Va166Met polymorphism is possibly correlated with impairment of cognitive function in patients with major depressive disorder.